Results 71 to 80 of about 80,757 (307)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The At Issue Maturity of Corporate Bonds: The Influence of Credit Rating, Security Level, Duration and Macreoconomic Conditions [PDF]

open access: yes
We examine the determinants of the at issue time to maturity of corporate bonds. We find evidence that corporations partly determine the at issue maturity of bonds by responding to economic conditions.
Geetajali Bali, Frank Skinner
core  

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Effects of temperature sum on vitamin C concentration and yield of sea buckthorn (Hippophae rhamnoides) fruit: optimal time of fruit harvest

open access: yesAgricultural and Food Science, 1993
To investigate the effects of temperature sum on vitamin C concentration (Vc), yield and maturity of sea buckthorn fruit (Hippophae rhamnoides L.) and to predict the optimal harvest time, berries were collected from eight genotypes at an interval of ...
Yingmou Yao
doaj   +2 more sources

Genetic parameters and association between agronomic traits in special-grain common bean (Phaseolus vulgaris L.) genotypes

open access: yesRevista de la Facultad de Ciencias Agrarias, 2020
Estimates of genetic parameters allow to determine the genetic variability present in a population, and constitute one of the initial steps in a breeding program.
Carla Medianeira Giroletta dos Santos   +4 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

GATA1 deletion in human pluripotent stem cells increases differentiation yield and maturity of neutrophils. [PDF]

open access: yesiScience, 2023
Harper TC   +8 more
europepmc   +1 more source

Defining Benchmark Status: An Application using Euro-Area Bonds [PDF]

open access: yes
The introduction of the euro on 1 January 1999 created the conditions for an integrated government bond market in the euro area. Using a unique data set from the electronic trading platform Euro-MTS, we consider what is the benchmark' in this market.
Peter G. Dunne   +2 more
core  

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