Results 201 to 210 of about 862,564 (268)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Visible-light promoted cascade annulation of <i>N</i>-propargylamines with sodium sulfinates to access sulfonylated 9<i>H</i>-pyrrolo[1,2-<i>a</i>]indoles and quinolines. [PDF]

RSC Adv
Wu J, Dong H, Li Z.
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Chiral cyclopropenimine-catalyzed enantioselective Michael reactions of phenol and benzofuran-derived α,β-unsaturated pyrazolamides with benzophenone-imine of glycine esters. [PDF]

Beilstein J Org Chem
Bai Y, Wang XY, Zhu SK, Shen YT, Zhang SY, Wang PA.   +5 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor-Donor Diazo Compounds. [PDF]

Angew Chem Int Ed Engl
George V, Pattanaik A, Maddox D, Sigmund LM, Mejia G, Pahlén S, Angerer SO, Schmoll M, Schneider LM, Selmi N, Kabeshov M, Bergonzini G, Rehbein J, König B.   +13 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Unified Gold(I/III)-Catalyzed Arylative, Vinylative, and Alkynylative Lactonization via Iminium-Directed Cyclization Enabled by Hemilabile Ligands. [PDF]

Org Lett
Herrera-Luna JC, Mobili R, Ollivier C, Mouriès-Mansuy V, Fensterbank L.   +4 more
europepmc   +1 more source

Fe(porphyrin)-Catalyzed Alkene Epoxidation with NaOCl: A Practical Small- and Large-Scale Alternative to <i>m</i>CPBA. [PDF]

J Am Chem Soc
Maiti S, Baek D, Stahl SS.
europepmc   +1 more source

Installing Axial Chirality by Atroposelective C(sp³)-H Bond Oxidation. [PDF]

J Am Chem Soc
Borrell M, Galeotti M, Vicens L, Mintz T, Call A, Pappo D, Costas M.   +6 more
europepmc   +1 more source