Results 151 to 160 of about 112,331 (313)

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

open access: yesJournal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad   +3 more
wiley   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

open access: yesJournal of Intelligent Medicine, EarlyView.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen   +3 more
wiley   +1 more source

Liebig Review: Essential and Beneficial Elements in the Regulation of Cadmium Uptake and Tolerance in Crop Plants

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Cadmium (Cd2+) contamination in agricultural soils has been reported to pose risks to crop productivity, food safety, and human health. This review synthesizes current knowledge on the mechanisms by which essential (S, Zn, Fe, Mg, K, Ca) and beneficial (Si, Se, rare earth elements) elements mitigate Cd2+ toxicity in plants.
Maria Manzoor, Karl Hermann Mühling
wiley   +1 more source

Maintaining egg freshness in the absence of refrigeration: The potential of zero‐energy cooling pots

open access: yesJSFA reports, EarlyView.
Abstract Background Egg storage in regions with unreliable electricity is challenging, leading to rapid quality deterioration and postharvest losses. This study evaluated the efficacy of a Zero‐Energy Cooling (ZEC) pot, an evaporative cooling technology, for preserving table egg quality in comparison to conventional refrigeration and ambient storage ...
Thomas Ansong Agyei   +4 more
wiley   +1 more source

Evaluating the combined toxicity of Penicillium mycotoxins in absorption, metabolism, and excretion systems

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Penicillium mycotoxins, including ochratoxin A (OTA), citrinin (CIT), and cyclopiazonic acid (CPZ), frequently co‐occur in food commodities, contributing to chronic low‐level dietary exposure. However, current risk assessments often consider these toxins individually, overlooking potential interaction effects.
Carolina Sousa Monteiro   +3 more
wiley   +1 more source

Assessing the hidden risks of non‐thermal processing: Ultrasound‐induced toxicity of cashew apple juice in a zebrafish model

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Background High‐intensity ultrasound is widely advocated for the preservation of liquid foods; however, the potential formation or release of toxic compounds during processing remains under‐investigated. This study evaluated the toxicological profile of cashew apple juice processed by high‐intensity ultrasound (1250, 1875, and 2500 W;L⁻¹ ...
Thaiz Batista Azevedo Rangel Miguel   +5 more
wiley   +1 more source

Approximation of the yolk by the LP yolk

open access: yes
If n points are sampled independently from an absolutely continuous distribution with support a convex subset of [real]2, then the center and radius of the ball determined by the bounding median lines (the LP yolk) converge with probability one to the ...
Tovey, Craig A., McKelvey, Richard
core  

The Role of HUWE1 on Mouse Neural Cell Proliferation and Zebrafish Neurodevelopment

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT The HECT, UBA, and WWE domain‐containing E3 ubiquitin protein ligase 1 (HUWE1) gene is located on the X chromosome and has been implicated in neurodevelopmental disorders. However, the mechanisms by which HUWE1 dosage affects nervous system development remain poorly understood. In this study, we demonstrate that HUWE1 overexpression suppresses
Haojuan Wu   +10 more
wiley   +1 more source

Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny. [PDF]

open access: yesNat Struct Mol Biol
Aupérin N   +10 more
europepmc   +1 more source

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