Results 111 to 120 of about 10,690,970 (310)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
To Have and to Hold: An Analysis of Young Adult Debt [PDF]
, 2006 Today's young adults often have been characterized as a generation of borrowers. But are they any different from past generations, or the current generation of adults, in the amount of debt they carry?In this Issue Brief Ngina Chiteji takes a careful ...
Ngina S. Chiteji
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Young module multiplicities and classifying the indecomposable Young permutation modules [PDF]
, 2015 We study the multiplicities of Young modules as direct summands of permutation modules on cosets of Young subgroups. Such multiplicities have become known as the p-Kostka numbers.
Gill, Christopher C.
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
THEORETICAL STUDY OF YOUNG INFRACTORS PERSONALITY THAT COMMITED CRIMES AGAINST THE PATRIMONI [PDF]
Psihologie, 2018 This article describes through theoretical point of view the personality traits of young offenders who have committed crimes against patrimony. There are a lot of similar characteristics of them with other types of offenders but at the same time there ...
Stanislav CEBOTARI
doaj
Young People and Digital Intimacies. What is the evidence and what does it mean? Where next? [PDF]
, 2019 The digital age makes new forms of connection possible, enabling ‘digital intimacies’ including the many practices of communicating, producing and sharing intimate content (‘sexting’; selfies; making, viewing and circulating sexual content; using hook-up
Attwood, Feona +2 more
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source