Results 211 to 220 of about 10,690,970 (310)

Aberrant dopaminergic activity during consolidation causes age-related memory generalization in Drosophila. [PDF]

PLoS Biol
Matsuno M, Uemura N, Miyashita T, Kobayashi KS, Liotta A, Kimura M, Ofusa K, Owald D, Matsuo N, Saitoe M, Horiuchi J.   +10 more
europepmc   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Evaluation of Clinical Characteristics and Lung Function Trajectories in Young COPD Patients Within the General Population. [PDF]

Int J Chron Obstruct Pulmon Dis
Nam JH, Rhee CK, Jo YS, Kim S, Kim YS, Kim SH, Kim KH, Choi JY.   +7 more
europepmc   +1 more source

Obesity subtypes and longitudinal trajectories of function over 7‐years of follow‐up: data from the Multicenter Osteoarthritis Study

Arthritis Care &Research, Accepted Article.
Background Obesity, defined by BMI ≥30kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA.
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi   +6 more
wiley   +1 more source

Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer's disease pathogenesis. [PDF]

Nat Aging
Tabuena DR, Jang SS, Grone B, Yip O, Aery Jones EA, Blumenfeld J, Liang Z, Mann RS, Li Y, Necula D, Koutsodendris N, Rao A, Ding L, Zhang AR, Hao Y, Xu Q, Yoon SY, De Leon S, Huang Y, Zilberter M.   +19 more
europepmc   +1 more source

New Deal For Young People: Evaluation Of Unemployment Flows [PDF]

David Wilkinson
core  

Clinical, histological, and serological predictors of renal function loss in lupus nephritis.

Arthritis Care &Research, Accepted Article.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M Guthridge, Carla Guthridge, Peter Izmirly, Jill P Buyon, H.Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership RA/SLE Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

Co-creating a program theory and evaluability assessment for an Irish single-session, synchronous chat-based youth mental health intervention: implications for outcome evaluation. [PDF]

Front Digit Health
Tibbs M, Dwan-O'Reilly M, Carey A, Moore J, Fitzgerald A.   +4 more
europepmc   +1 more source

The Physician‐Scientist Pipeline for Pediatric Rheumatology – Current Landscape and Future Perspectives.

Arthritis Care &Research, Accepted Article.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

The Role of Dopamine Signaling and Neuroinflammation in Age-Related Cognitive Dysfunction. [PDF]

Brain Behav
Bowen J, Hanna K, Young AMJ, Helfer G, McLean SL.   +4 more
europepmc   +1 more source