Results 21 to 30 of about 11,368,498 (352)

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

New England Journal of Medicine, 2018
Background In a single‐center phase 1–2a study, the anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy tisagenlecleucel produced high rates of complete remission and was associated with serious but mainly reversible toxic effects in children and ...
S. Maude, T. Laetsch, J. Buechner, S. Rives, M. Boyer, H. Bittencourt, P. Bader, M. Verneris, H. Stefanski, G. D. Myers, M. Qayed, B. De Moerloose, H. Hiramatsu, Krysta D Schlis, K. Davis, P. Martin, Eneida R. Nemecek, G. Yanik, C. Peters, A. Baruchel, N. Boissel, F. Mechinaud, A. Balduzzi, J. Krueger, C. June, B. Levine, P. Wood, T. Taran, M. Leung, K. Mueller, Yiyun Zhang, K. Sen, D. Lebwohl, M. Pulsipher, S. Grupp   +34 more
semanticscholar   +1 more source

Increases in Loneliness Among Young Adults During the COVID-19 Pandemic and Association With Increases in Mental Health Problems

Journal of Adolescent Health, 2020
Purpose Young adults are at high risk for increases in loneliness and mental health problems during the COVID-19 pandemic. The present study examined increases in loneliness in a young adult sample, for whom increases were greater, and association with ...
Christine M. Lee, Jennifer M. Cadigan, Isaac C. Rhew   +2 more
semanticscholar   +1 more source

Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Adolescents and young adults with type 1 diabetes exhibit the worst glycemic control among individuals with type 1 diabetes across the lifespan. Although continuous glucose monitoring (CGM) has been shown to improve glycemic control in adults,
L. Laffel, L. Kanapka, Roy W. Beck, Katherine Bergamo, Mark A Clements, A. Criego, Daniel J. Desalvo, R. Goland, K. Hood, D. Liljenquist, Laurel H. Messer, R. Monzavi, Thomas J. Mouse, Priya Prahalad, J. Sherr, Jill H. Simmons, R. Wadwa, Ruth S. Weinstock, S. Willi, K. Miller   +19 more
semanticscholar   +1 more source

Suicidality Prevalence in a Pediatric Psychiatric Clinic: Relation to Social and Environmental Risk Factors

Children, 2023
Suicidality is a growing public health problem in children and adolescents. The aim of this retrospective data analysis study was to estimate the prevalence of suicidality in pediatric patients admitted to an academic Pediatric Psychiatric Clinic (PPC ...
Stavroula Ilia, Evangelia Sakapeti, Panagiotis Briassoulis, George Gerostergios, Alexandros Vgontzas, George Briassoulis   +5 more
doaj   +1 more source

Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease

Kidney International, 2020
Using data (2655 observations from 928 participants) from the Chronic Kidney Disease in Children Study, we developed and internally validated new glomerular filtration rate estimating equations for clinical use in children and young adults: two forms of ...
C. Pierce, Alvaro Muñoz, Derek K. Ng, B. Warady, S. Furth, G. Schwartz   +5 more
semanticscholar   +1 more source

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

The Lancet, 2014
Summary Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of ...
Daniel W. Lee, J. Kochenderfer, M. Stetler-stevenson, Yong-Zhi Cui, Cindy P. Delbrook, S. Feldman, T. Fry, R. Orentas, M. Sabatino, N. Shah, S. Steinberg, D. Stroncek, Nick Tschernia, Constance M. Yuan, Hua Zhang, Ling Zhang, S. Rosenberg, A. Wayne, C. Mackall   +18 more
semanticscholar   +1 more source

Spontaneous mapping of number and space in adults and young children

Cognition, 2008
Mature representations of space and number are connected to one another in ways suggestive of a ‘mental number line’, but this mapping could either be a cultural construction or a reflection of a more fundamental link between the domains of number and ...
M. D. de Hevia, Elizabeth S. Spelke
semanticscholar   +1 more source

Severe Coronavirus Disease-2019 in Children and Young Adults in the Washington, DC, Metropolitan Region

Jornal de Pediatria, 2020
Despite worldwide spread of severe acute respiratory syndrome coronavirus-2, few publications have reported the potential for severe disease in the pediatric population.
R. DeBiasi, Xiaoyan Song, M. Delaney, M. Bell, Karen L. Smith, J. Pershad, E. Ansusinha, A. Hahn, R. Hamdy, N. Harik, B. Hanisch, B. Jantausch, A. Koay, R. Steinhorn, Kurt D. Newman, D. Wessel   +15 more
semanticscholar   +1 more source

Development of Physical Fitness among the Top 10 Boys and Girls in Sport Schools: A 10-Year Cohort Analysis

Sports, 2019
In this study, we aimed to measure the development of physical fitness (PF) of 10 different cohorts in grade 4 and 8 different cohorts in grade 7 at 18 sport schools of North Rhine-Westphalia, Germany.
Andreas Roth, Steffen C. E. Schmidt, Sina Hartmann, Ilka Seidel, Swantje Scharenberg, Klaus Bös   +5 more
doaj   +1 more source

Ischaemic stroke in young adults: a global perspective

Journal of Neurology Neurosurgery & Psychiatry, 2020
Ischaemic stroke at young age is an increasing problem in both developing and developed countries due to rising incidence, high morbidity and mortality and long-term psychological, physical and social consequences.
Esther M. Boot, M. Ekker, J. Putaala, S. Kittner, F. de Leeuw, A. Tuladhar   +5 more
semanticscholar   +1 more source