Results 151 to 160 of about 4,117,281 (337)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A new method for identifying and evaluating depressive disorders in young people based on cognitive neurocomputing: an exploratory study

Frontiers in Computational Neuroscience
BackgroundDepressive disorders are one of the most common mental disorders among young people. However, there is still a lack of objective means to identify and evaluate young people with depressive disorders quickly.
Jiakang Liu, Kai Li, Kai Li, Shuwu Li, Shangjun Liu, Chen Wang, Shouqiang Huang, Yuting Tu, Bo Wang, Pengpeng Zhang, Yuntian Luo, Guanqun Sun, Tong Chen   +12 more
doaj   +1 more source

The Effects of Respiratory Muscle Functions on Trunk Muscle Endurance in Healthy Young Adults

, 2023
Özge Ocaker Aktan, Rıdvan Aktan, Hazal Yakut, Sevgi Özalevli, Bilge Kara   +4 more
openalex   +1 more source

Population-level detection of early loss of kidney function: 7-year follow-up of a young adult cohort at risk of Mesoamerican nephropathy [PDF]

, 2023
Marvin González-Quiroz, Brianna Heggeseth, Armando Camacho, Amin Oomatia, Ali M. Al-Rashed, Yixuan Zhang, Alexander McCreight, Nicholas P. Jewell, Aurora Aragón, Dorothea Nitsch, Neil Pearce, Ben Caplin   +11 more
openalex   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

THE CORRELATION BETWEEN MOTOR QUALITIES AND HEART PUMPING FUNCTION RESERVES IN YOUNG ATHLETES

, 2020
N. I. Abzalov, R. A. Abzalov, Р. А. Абзалов   +2 more
openalex   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Pulmonary function assessment in young female medical students suffering from anemia

, 2014
Sharad Jain, Joel Agarwal
openalex   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source