Results 221 to 230 of about 4,003,229 (276)

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

open access: yesSensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa   +5 more
wiley   +1 more source

Resource reallocation across successive systemic innovations: How Rolls‐Royce shaped the evolution of the turbojet, turboprop, and turbofan

open access: yesStrategic Management Journal, EarlyView.
Abstract Research Summary Despite the importance of resource reallocation in shaping a variety of strategic outcomes, strategy scholars have paid only limited attention to the processes by which firms reallocate their resources across successive systemic innovations.
Gino Cattani   +2 more
wiley   +1 more source

Earth-mass planets with He atmospheres in the habitable zone of Sun-like stars. [PDF]

open access: yesNat Astron
Lammer H   +6 more
europepmc   +1 more source

Solar‐Powered Water Depollution Through a Bioinspired Device Based on ZIF‐8 Loaded Macroporous Hydrogels Prepared via Ice‐Templating

open access: yesSmall, EarlyView.
ABSTRACT Water pollution poses a constant threat to the environment and is one of the central causes for global shortage of clean water. Metal–Organic Frameworks (MOFs) have emerged as highly efficient adsorbents; however, their application is limited by their common production as fine powders, which hinders recovery and reuse.
Katsuya Komiyama   +3 more
wiley   +1 more source

Thermal Instability Pathways of Aluminum‐Based Nanocomposites: The Role of Alloying‐Element‐Driven Precipitation and Amorphous Interlayers

open access: yesSmall, EarlyView.
Thermal instability mechanisms governing novel Al‐based PVD/ALD nanocomposites are uncovered through synchrotron XRD, STEM, APT, and micromechanical testing. Temperature‐dependent crystallite evolution reveals a defined stability window before degradation dominates, offering new insight into the design of thermally robust, functional Al‐based ...
Hendrik C. Jansen   +10 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

open access: yesSmart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin   +10 more
wiley   +1 more source

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