Results 41 to 50 of about 7,745,855 (296)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Rumours, myths, and misperceptions as barriers to contraceptive use among adolescent girls and young women in South Africa

Frontiers in Reproductive Health, 2022
BackgroundRumours, myths, and misperceptions about contraceptives are a barrier to contraceptive use in general, but more so among adolescent girls and young women (AGYW).
Kim Jonas, Kim Jonas, Zoe Duby, Zoe Duby, Kealeboga Maruping, Jane Harries, Catherine Mathews, Catherine Mathews   +7 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Young Women’s Political Participation and Gender Depoliticization in Nigeria

Jurnal Studi Pemerintahan
Since return to Nigeria to civilian administration in 1999, women have been making efforts to access political leadership space with little progress.  With international and national instruments to ensure more women gain inroad into politics, there is a ...
Adeola Aderayo Adebajo, Owolola Oluwakemi Yusirat, Adebajo Olatomiwa Abraham, Adebajo Adesola Seun   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

A Histopathology Study of Caspian Seal (Pusa caspica) (Phocidae, Mammalia) Liver Infected with Trematode, Pseudamphistomum truncatum (Rudolphi, 1819) (Opisthorchidae, Trematoda)

Iranian Journal of Parasitology, 2014
Background: Main objective of this study was to investigate the invasive activity of the liver fluke, Pseudamphistomom truncatum against the Caspian seal (Pusa caspica) and was exemplified at the gross, light microscopy (LM) and electron microscopy (EM ...
Richard Heckmann, Ali Halajian, Atif El-Naggar, Wilmien Luus-Powell   +3 more
doaj  

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Sexual Excitation in Young Women with Different Levels of Sexual Satisfaction in Relationships: A Laboratory Study

Behavioral Sciences
Sexual satisfaction is an important dimension of sexual health. Despite there being evidence about its relations with sexual arousal, this association has not been addressed considering arousal as a trait and as a state.
María del Mar Sánchez-Fuentes, Ana Álvarez-Muelas, Oscar Cervilla, Reina Granados, Juan Carlos Sierra   +4 more
doaj   +1 more source

Young Women with Breast Cancer in Resource-Limited Settings: What We Know and What We Need to Do Better

Breast Cancer: Targets and Therapy, 2021
Bertha Alejandra Martinez-Cannon,1,2,* Regina Barragan-Carrillo,1,2,* Cynthia Villarreal-Garza2,3 1Hematology-Oncology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico; 2Joven & Fuerte: Programa
Martinez-Cannon BA, Barragan-Carrillo R, Villarreal-Garza C   +2 more
doaj