Results 171 to 180 of about 2,750,733 (346)

Probing the Challenge of P‐Type Semiconductors in Long‐Chain VOC Detection: 3D Micro‐Flower Zinc Cobaltate Heterojunction Sensors

open access: yesAdvanced Science, EarlyView.
Fe@WO3/ZnCo2O4 n‐p heterojunction sensor exhibits excellent room‐temperature sensing toward tetradecane, with a low detection limit of 78.4 ppb and short recovery time. The good performance is attributed to synergistic effects from heterojunctions, heteroatom doping, oxygen vacancies, high‐energy facets, and theoretical validations.
Kewei Liu   +5 more
wiley   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

open access: yesAdvanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu   +12 more
wiley   +1 more source

Latent class analysis of actigraphy within the depression early warning (DEW) longitudinal clinical youth cohort

open access: yesChild and Adolescent Psychiatry and Mental Health
Background Wearable-generated data yield objective information on physical activity and sleep variables, which, are in turn, related to the phenomenology of depression.
Lydia Sequeira   +7 more
doaj   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

open access: yesAdvanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma   +9 more
wiley   +1 more source

A Nanomodulator Enhances Radiotherapy‐Induced In Situ Cancer Vaccine by Promoting Antigen‐Presenting of Tumor‐Associated Macrophage

open access: yesAdvanced Science, EarlyView.
A nanomodulator (Ft‐E64/Hf@Lipo) is developed, combining radiosensitizer hafnium (Hf) and the cysteine protease inhibitor E64, which cooperatively reinvigorated the antigen presentation of TAMs. Ft‐E64/Hf@Lipo sensitized‐RT generated abundant tumor neoantigens, and then E64/antigens, along with the apoptotic tumor cells, trafficked to TAMs via ...
Xiu Zhao   +9 more
wiley   +1 more source

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