Results 281 to 290 of about 16,224,136 (409)

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Retention in Junior Giants, a sport-based youth development program: what factors are associated with intentions to return? [PDF]

Front Sports Act Living
Bolter ND, Kipp LE, Greenwood PB.
europepmc   +1 more source

Relationships of Activity and Sugar Drink Intake on Fat Mass Development in Youths

, 2006
Clark Mundt, Adam Baxter‐Jones, Susan J. Whiting, D. A. Bailey, Robert A. Faulkner, Robert L. Mirwald   +5 more
openalex   +1 more source

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

Advanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong, Chun‐Ye Chen, Zi‐Xuan Feng, Yong Wang, Tao Zhang, Ze‐Ming Zhuang, Zhang‐Rui Wu, Yong‐Zhong Du, Jun Chen, Xiao‐Ying Lin, Wei‐Qiang Tan   +10 more
wiley   +1 more source

Measuring Character Strengths and Promoting Positive Youth Development in Zambia: Initial Findings from the GROW Hopes for Life Study. [PDF]

Child Youth Care Forum
Tirrell JM, Sampa M, Wootten K, Harris SK, McGrath RE, Mulavu M, Sindano N, Kasanga L, Mweemba O, Seale DM, Seale JP, Mutale W.   +11 more
europepmc   +1 more source

Development of Youth Leadership Life Skills of Texas Youth as San Antonio Livestock Exposition School Tour Guides

, 2006
Laura A. Real, Julie F. Harlin
openalex   +1 more source

Non‐Bonded Interaction Driven Morphology Evolution of CuMOF@MXene Energetic Composites: Synergistic Optimization of Thermal Stability and Combustion Performance

Advanced Science, EarlyView.
This work presents a strategy for preparing energetic composites based on energetic metal‐organic frameworks and MXene. This approach leverages the interfacial “Ti─O···Cu” non‐bonded interactions to achieve energetic composites with diverse morphologies and performance.
Ke‐Juan Meng, Xinwen Ma, Kunyu Xiong, Xiaoxia Ma, Iftikhar Hussain, Momang Tian, Kaili Zhang   +6 more
wiley   +1 more source

Selecting Statewide Youth Development Outcome Indicators

, 2006
Michael Surko, Lawrence W. Pasti, Janis Whitlock, Deborah A. Benson   +3 more
openalex   +1 more source

Comparative Single‐Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of river and swamp buffalo, encompassing 12 tissues and 397,011 cells, is constructed. Differential expression analyses identify metabolic and secretory tissues and cell types that mediate the divergence of milk production.
Dongmei Dai, Jingfang Si, Li Jiang, Bo Han, Kailai Wang, Xue Wang, Shihui Yan, Yichang Yin, Wei Chen, Huaming Mao, Alfredo Pauciullo, Shang‐Tong Li, Lingzhao Fang, Yi Zhang   +13 more
wiley   +1 more source

A Pathway to Positive Youth Development: Unpacking the Asian American Youth Paradox and Cultural Orientations among Filipino American and Korean American Youth. [PDF]

Children (Basel)
Choi Y, Park M, Yasui M.
europepmc   +1 more source