Results 291 to 300 of about 16,224,136 (409)

Bispecific Nanosystems Enable Multieffector Immune Cell Retargeting for Hematologic Malignancy Therapy

open access: yesAdvanced Science, EarlyView.
B‐cell lymphomas are aggressive malignancies with limited treatment options. A bispecific nanosystem (biHSNPs) is developed, leveraging silica nanoplatforms to conjugate antibodies targeting immune effector cells and B‐cell antigens. biHSNPs form artificial immunological synapses, activating cytotoxic responses and suppressing tumor proliferation. This
Yefeng Shen   +12 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

open access: yesAdvanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei   +18 more
wiley   +1 more source

Solvent Replacement‐Driven Ionic Liquid Thermoelectric Gel for Self‐Powered Morse Code Communication Assisted by Machine Learning

open access: yesAdvanced Science, EarlyView.
A solvent replacement method is employed to transform PMAA hydrogel into a PMAA IL gel. The assembled thermoelectric device demonstrated stable voltage output and temperature sensitivity across a wide operating temperature range. Additionally, a self‐powered communication system integrating the PMAA IL gel with a logistic regression model is developed,
Lingshuang Kong   +4 more
wiley   +1 more source

Introducing 4-H Youth Development

open access: bronze, 2006
Marilyn N. Norman, Joy C. Jordan
openalex   +2 more sources

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