Results 151 to 160 of about 152,203 (283)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Challenges in Transitioning Single-Stream Colleges into Multidisciplinary Institutions Under NEP 2020

The Achievers Journal: Journal of English Language, Literature and Culture
The transition of single-stream colleges into multidisciplinary institutions, as envisioned under NEP 2020, marks a transformative shift in India's higher education landscape.
Gurpal Singh Rana
doaj  

Response of some faba bean genotypes to heat stress under environmental variations. [PDF]

BMC Plant Biol
Asaad MR, El-Hashash EF, Ridwan ARM.
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Differential analysis of gut microbiota between captive and wild forest musk deer (<i>Moschus berezovskii</i>) based on 16S rRNA sequencing. [PDF]

Front Vet Sci
Lu M, Zhu L, Dai K, Wang Y, Yao S, Li S, Xie Z.   +6 more
europepmc   +1 more source

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

Advanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju, Adithya Umanath Rai, Jose Thomson, Marzie Ghorbani, Shujing Zhao, Nick Birbilis   +5 more
wiley   +1 more source

UPLC-MS/MS analysis and bioactivity comparison of wild and cultivated <i>Taihangia rupestris</i> leaves: antioxidant and α-glucosidase inhibitory activities with active compound screening. [PDF]

RSC Adv
Yin JT, Wang DM, Wu XC, Lu J, Qian ZM, Li DQ, Feng R.   +6 more
europepmc   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Ultrasonographic features of 5-aminosalicylic acid intolerance in pediatric ulcerative colitis. [PDF]

Clin Exp Pediatr
Murashige H, Sakata Y, Azuma Y, Hasegawa S.   +3 more
europepmc   +1 more source

Getting your Ys crossed [PDF]

Nature Reviews Genetics, 2009
openaire   +1 more source