Results 221 to 230 of about 834,251 (282)

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

open access: yesAdvanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen   +15 more
wiley   +1 more source

Real‐Time Digital Micromotor Tracking‐Enabled Ultrasensitive Immunoassay

open access: yesAdvanced Science, EarlyView.
An AI‐facilitated real‐time digital micromotor tracking‐enabled immunoassay is developed, which leverages a self‐developed multi‐microparticle tracking system to monitor micromotor motion trajectories in a real‐time manner for digital protein analysis.
Jingjing Shi   +6 more
wiley   +1 more source

Summer School and YS meeting

open access: yes
The Summer School organized by month 30 combined with the Young Scientists Workshop will be a distinct event independent of the Training WorkshopsProgress meetings The main goal of the School will be to provide the participants with an opportunity to gain indepth knowledge of ZULF related topics and in contrast to Progress Meetings it will be partially
openaire   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

open access: yesAdvanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu   +9 more
wiley   +1 more source

Redox‐Active NiOx‐Catalyzed Li+ Capture‐Extraction Strategy for tBP‐Free Spiro‐OMeTAD Enables Exceptional Damp‐Heat Stability in Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
The redox‐active nature of NiOx enables ultrafast oxidative doping of spiro‐OMeTAD within seconds. Concurrently, NiOx‐Li+ coordination complexes formed during this redox process are selectively removed by filtration, effectively extracting residual Li+ ions from the film.
Yun Seop Shin   +19 more
wiley   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

open access: yesAdvanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling   +17 more
wiley   +1 more source

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