Results 31 to 40 of about 2,125,664 (226)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Inclusion of Quantum Fluctuations in Wave Packet Dynamics
, 1996 We discuss a method by which quantum fluctuations can be included in microscopic transport models based on wave packets that are not energy eigenstates.
Ohnishi, A., Randrup, J.
core +1 more source
Dexmedetomidine potently and reversibly regulates stress-mediated behaviors
Frontiers in PharmacologyAimsDemonstrate that dexmedetomidine is potentially useful for treatment of psychiatric symptoms caused by acute or chronic stress by using relevant rodent models and doses predicted to achieve sufficient brain levels to activate alpha2-adrenoceptors ...
Frank D. Yocca +7 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
On bulk singularities in the random normal matrix model [PDF]
, 2016 We extend the method of rescaled Ward identities of Ameur-Kang-Makarov to study the distribution of eigenvalues close to a bulk singularity, i.e. a point in the interior of the droplet where the density of the classical equilibrium measure vanishes.
A Soshnikov +20 more
core +2 more sources
Journal of Entomological and Acarological Research, 2011 A list of the scale insects (Homoptera: C occoidea) recorded by the authors for the Greek island of C rete is reported. This includes twenty-seven species new to the island The most interesting records are Kermes palestiniensis Balachowsky (Kermesidae ...
Giuseppina Pellizzari +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Localization and Toeplitz Operators on Polyanalytic Fock Spaces [PDF]
, 2011 The well know conjecture of {\it Coburn} [{\it L.A. Coburn, {On the Berezin-Toeplitz calculus}, Proc. Amer. Math. Soc. 129 (2001) 3331-3338.}] proved by {\it Lo} [{\it M-L. Lo, {The Bargmann Transform and Windowed Fourier Transform}, Integr. equ.
Faustino, Nelson
core
Coupling and an application to level-set percolation of the Gaussian free field
, 2016 We consider a general enough set-up and obtain a refinement of the coupling between the Gaussian free field and random interlacements recently constructed by Titus Lupu in arXiv:1402.0298.
Sznitman, Alain-Sol
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source