Results 151 to 160 of about 14,410,842 (233)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses Anna M. Dowbaj, Meritxell Huchwiley +1 more sourceThe microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri +3 morewiley +1 more sourceSearch for lepton flavour number violating Z(0)-decays
, 1997 A search for lepton flavour number violating Z(0) decays in the channels Z(0) –> mu tau, Z(0) –> e tau, Z(0) –> e mu, using the DELPHI detector with data collected during the 1991-94 LEP runs, is described, No signal was found.Kluit, P, Pape, L, Kreuter, C, Carroll, L, Chabaud, V, Parodi, F, Jalocha, P, Olshevski, AG, Nomerotski, A, Koene, B, Ripp, I, Pages, P, Becks, KH, Sponholz, P, Grzelak, K, Camporesi, T, Dauncey, PD, Sacquin, Y, Rahmani, H, Gracco, V, Gumenyuk, S, Fuster, J, TGM, Grosdidier, G, Lemonne, J, Kurvinen, K, B, Sedykh, Y, C, Nawrocki, D, Cossutti, F, Libby, J, F, G, Loukas, D, K, L, Margoni, M, M, P, S, Contri, R, Botner, O, Michelotto, M, V, Bilenky, MS, Gasparini, U, Mariotti, C, Grefrath, A, Tilquin, A, Abreu, P, DiDiodato, A, Houlden, M, Liko, D, Khovanski, NN, Myatt, G, Navas, S, Barrio, JA, Renton, PB, Sahr, O, Redaelli, NG, DePaula, L, Parkes, C, Gimenez, MVC, Brenner, RA, Marechal, Caccia, M, Jackson, Koratzinos, M, Tkatchev, LG, Ajinenko, I, Obraztsov, V, Schyns, MAE, Fichet, S, Kaiser, M, Paganini, P, Kjaer, NJ, Khokhlov, Y, Passeri, A, EN, Gele, D, Brand, Osterberg, Peralta, L, Higon, E, McKay, R, Seager, P, Hill, TS, Rosenberg, EI, Saarikko, H, Nikolaenko, V, Marco, J, Brenke, T, DeClercq, C, Podobrin, O, Marco, R, Lamsa, JW, Shellard, RC, Ferrer, A, Kostioukhine, V, Roncagliolo, I, Bertini, D, Hessing, TL, Krammer, M, Lippi, I, Joram, C, Matteuzzi, C, Lesiak, T, DeBrabandere, S, Tchikilev, O, Karafasoulis, K, Cabrera, S, Sisakian, AN, Barbi, M, Nieuwenhuizen, M, Henriques, R, Lefebure, V, Smith, GR, Calvi, M, Mazzucato, M, Morettini, P, Resvanis, LK, Czellar, S, Holthuizen, D, OberschulteBeckmann, W, DeBoer, W, Moeller, R, Graziani, E, Galloni, A, Lyons, L, Augustin, JE, Barao, F, DellaRicca, G, Reale, M, Frodesen, AG, Hahn, S, Naraghi, F, Ridky, J, Foeth, H, DeSaintJean, C, Chochula, P, Kapusta, Bonesini, M, Hahn, F, Sadovsky, A, Bizouard, MA, Engel, JP, Firestone, A, Buschmann, P, Timmermans, J, Schimmelpfennig, M, Bianchi, JN, Fontanelli, F, Sosnowski, R, Blume, M, Bigi, M, Jonsson, Holmgren, SO, KD, Gunnarsson, P, Booth, PSL, Koenig, K, Cattai, A, Khomenko, BA, Feindt, M, Charpentier, P, Janik, R, Tcherniaev, E, Andreazza, A, Golob, B, Hedberg, V, Gerber, JP, Stevenson, K, Ledroit, F, Djama, F, Ouraou, A, Bourdarios, C, Carena, F, FuldaQuenzer, F, RuhlmannKleider, V, Baillon, P, Rozas, AJC, Fokitis, E, Jarlskog, G, Legan, CK, Meyer, WT, Mandl, F, Silvestre, R, Smirnov, N, Alekseev, GD, Gris, P, Jarlskog, C, MartinezVidal, F, Cosme, G, Hernandez, JJ, Katsoufis, EC, Drees, KA, Navarria, FL, Phillips, HT, Chudoba, J, Cortina, E, Migliore, E, Dris, M, Keranen, R, Mueller, H, Seitz, A, Almehed, S, DeLotto, B, DeMin, A, JeanMarie, B, Dijkstra, H, Spassov, T, Meyer, S, Perrotta, A, Franek, B, Privitera, P, Rosso, E, Roos, L, Richardson, J, Merk, M, Pain, R, Niss, P, Edsall, D, Donszelmann, M, Rebecchi, P, Stapnes, S, Gorski, M, Pierre, F, Smirnova, O, Falk, E, Murray, WJ, Battaglia, M, Maestro, JC, Billoir, P, Pegoraro, M, Maio, A, Petrolini, A, Adam, W, Canale, V, Siegrist, P, Muryn, B, Cankocak, K, Novak, M, Gopal, G, Poropat, P, Papadopoulou, TD, Juillot, P, Ehret, R, Garcia, SMI, Frenkiel, Gorn, L, DeAngelis, A, Paganoni, M, Bonivento, W, Apel, WD, Pimenta, M, SouzaSantos, D, Holt, PJ, Sciolla, G, Belous, K, Hoorelbeke, Klovning, A, Brunet, JM, Kubinec, P, Deghorain, A, Kouznetsov, O, Meroni, C, Neumann, W, Antilogus, P, Boudinov, E, Schneider, H, Kronkvist, I, Buran, T, Smadja, G, Petrovyck, M, Segar, AM, Hansen, J, Mirabito, L, Mulders, M, McCubbin, M, Skaali, TB, Gavillet, P, Besancon, M, Bouquet, B, Eigen, G, Gaspar, C, Nicolaidou, R, Regler, M, Damgaard, G, Monge, MR, Laktineh, I, Medbo, J, Dam, M, Lane, DW, Buys, A, Formenti, F, Krupinski, W, Crawley, HB, Markou, A, Bozzo, M, Belokopytov, Y, MacNaughton, J, Fischer, PA, Durand, JD, Sitar, B, Leitner, R, Neumeister, N, Sahm, J, Strauss, J, Simonetti, S, Hrubec, J, Bosio, C, Ruiz, A, Mjoernmark, U, Bowcock, TJV, Rybicki, K, Drees, J, Ekelof, T, Loken, JG, Benvenuti, AC, Nielsen, BS, Lapin, V, Rinaudo, G, Schwickerath, U, Maehlum, G, Spiriti, E, Dalmagne, B, Amato, S, Baudot, J, Beilliere, P, Alemany, R, MartinezRivero, C, Barring, O, Collins, P, Karlsson, M, Piana, G, Hamacher, K, Pol, ME, Amaldi, U, Branchini, P, Papageorgiou, K, Sekulin, R, Rovelli, T, Bricman, C, Kokkinias, P, Szczekowski, Chorowicz, V, King, B, Herquet, P, Gandelman, M, Normand, A, Erzen, B, Hajduk, Z, Sokolov, A, Crosetti, Fruhwirth, R, Radojicic, D, Lauhakangas, R, Malmgren, Thomas, J, Augustinus, A, Roudeau, P, Bates, MJ, Lenzen, G, Davenport, M, Bugge, L, Langefeld, P, Lacasta, Hilke, HJ, Chierici, R, Stanescu, Huet, K, Loerstad, B, Pozdniakov, Polok, G, Ronchese, P, Filippas, TA, Stocchi, A, Korcyl, K, Romero, A, Richard, F, Masik, J, Strub, R, Bertrand, D, Baroncelli, A, Kourkoumelis, C, Harris, FJ, Read, AL, Muenich, K, Matorras, F, Ruckstuhl, W, Lanceri, L, Jonsson, P, Dracos, M, Palka, H, Mundim, LM, Malychev, V, Pullia, A, Demaria, N, Ragazzi, S, Jacobsson, R, McNulty, R, Sajot, G, Simonetto, F, Pernegger, H, Gokieli, R, Hallgren, A, Laugier, JP, Salt, J, Gouz, Y, Matthiae, G, Squarcia, S, Adye, T, Herr, H, Elsing, M, Checchia, P, Leder, Katsanevas, S, Sannino, M, Lopez, JM, Gunther, M, Lipniacka, A, Moa, T, Burgsmueller, T, Chliapnikov, P, Lutz, P, Stichelbaut, F, Cindro, V, Green, C, DeLaVaissiere, C, Guy, J, Delpierre, P, Stavitski, I, Gamba, D, Ekspong, G, Asman, B, Petridou, C, Klapp, O, Brown, RCA, DaSilva, W, Barate, R, Ratoff, PN, Marin, JC, Szeptycka, M, Kucewicz, W, Allport, PP, Mahon, JR, Krumstein, Z, Bambade, P, Cowell, JH, Crennell, D, Sanchez, J, Bartl, W, Bloch, Lindner, R, Begalli, M, Jarry, P, Doroba, K, Johansson, EK, Berggren, M, Garcia, J, Dolbeau, J, Cavallo, FR, Stugu, B, Tabarelli, T, Hultqvist, K, Onofre, A, Karvelas, E, Garcia, C, Baubillier, M, Bardin, DY, Cao, F, Bolognese, T, Orava, R, Bruckman, P, Klein, H, Canepa, M, DahlJensen, E, Fassouliotis, D, Reid, D, Tavernet, JP, Mitaroff, WA, DiCiaccio, L, Chaussard, L, Fries, DC, Pukhaeva, N, Lepeltier, V, Caso, C, Gazis, Andrieux, ML, Defoix, C, Negri, P, Scuri, F, Serbelloni, L +495 morecore Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig +10 morewiley +1 more sourceLigand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada +5 morewiley +1 more source
