Results 191 to 200 of about 7,369,874 (310)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Bronchial thermoplasty reduces ventilation heterogeneity measured by phase-resolved functional lung magnetic resonance imaging in severe asthma. [PDF]

Respir Res
Foo CT, Langton D, Donovan GM, Thompson BR, Noble PB, Thien F.   +5 more
europepmc   +1 more source

K$_{\mbox{\fontsize{12pt}{14pt}\selectfont{\textit{s}}}}$-band luminosity function of thez= 1.237 cluster of galaxies RDCS J1252.9-2927 [PDF]

, 2003
Sune Toft, V. Mainieri, P. Rosati, C. Lidman, R. Demarco, M. Nonino, S. A. Stanford   +6 more
openalex   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

A Variational Quantum Eigensolver Based on the Measurement Scheme Tailored to Multiband Tight-Binding Simulations. [PDF]

J Chem Theory Comput
Lee D, Ryu H.
europepmc   +1 more source

The Evolution of the Galaxy Luminosity Function in the Rest-Frame Blue Band up to z =3.5 [PDF]

, 2003
F. Poli, E. Giallongo, A. Fontana, N. Menci, G. Zamorani, M. Nonino, P. Saracco, E. Vanzella, I. Donnarumma, S. Salimbeni, A. Cimatti, S. Cristiani, E. Daddi, S. D’Odorico, M. Mignoli, L. Pozzetti, A. Renzini   +16 more
openalex   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Prefrontal and parieto-occipital neural signatures of evidence accumulation and response to computerised Cognitive Behavioural Therapy in depression. [PDF]

Npj Ment Health Res
Queirazza F, Philiastides MG.
europepmc   +1 more source

The Munich Near-Infrared Cluster Survey -- V. The evolution of the rest-frame K- and J-band galaxy luminosity functions to z 0.7 [PDF]

, 2003
Georg Feulner, R. Bender, Niv Drory, U. Hopp, J. Snigula, Gary J. Hill   +5 more
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source