Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A Fully-Integrated Bayesian Approach for the Imputation and Analysis of Derived Outcome Variables With Missingness. [PDF]
Campbell H, Morris TP, Gustafson P.
europepmc +1 more source
Capture Zones of the Family of Functions λzmexp(z) [PDF]
Núria Fagella, Antonio Garijo
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Neurocognitive risk markers in first-episode major depressive disorder with positive family history: a large-scale case-control study. [PDF]
Li Z +7 more
europepmc +1 more source
Loss of function in protein Z (PROZ) is associated with increased risk of ischemic stroke in the UK Biobank [PDF]
Amelia K. Haj +11 more
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SPECTRAL ENERGY DISTRIBUTION OFz≳ 1 TYPE Ia SUPERNOVA HOSTS IN GOODS: CONSTRAINTS ON EVOLUTIONARY DELAY AND THE INITIAL MASS FUNCTION [PDF]
Matthew Thomson, Ranga‐Ram Chary
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AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Adult reference values for spirometry, body plethysmography and diffusing capacity adjusted for sex, age, weight, height or arm span - the Danish lung function material (DALFUMAT) study. [PDF]
Mortensen J +26 more
europepmc +1 more source
Galaxy Luminosity Functions to z~1: DEEP2 vs. COMBO-17 and Implications for Red Galaxy Formation
S. M. Faber +30 more
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