Results 271 to 280 of about 7,607,900 (314)

SyMetrics: an integrated machine learning model for evaluating the pathogenicity of synonymous variants in the human genome. [PDF]

NAR Genom Bioinform
Bundalian L, Strnadová MS, Garten F, Horn S, Stenzel U, Popp D, Lemke JR, Biskup S, Schulte B, May P, Bösebeck F, Garten A, Thor D, Schulz A, Hentschel J, Kelso J, Schöneberg T, Le Duc D.   +17 more
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Exploring the indicative role of ACT score in improving lung function in asthmatic children undergoing dust mite immunotherapy. [PDF]

BMC Pediatr
Zhang P, Ai T, Wang L, Luo R, Duan Y, Fan Y.   +5 more
europepmc   +1 more source

Nowoczesne technologie wspomagające funkcjonowanie osób z niepełnosprawnością w doświadczeniach Ośrodka Wsparcia i Testów w Sosnowcu = Modern technologies supporting the functioning of people with disabilities in the experiences of the Support and Testing Center in Sosnowiec [PDF]

Wolny, Jakub, Flanczewska-Wolny, Maria
openalex  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A modified minimally invasive subvastus approach shows superior early postoperative clinical outcomes compared to the medial parapatellar approach in total knee arthroplasty for osteoarthritis patients: a comparative study. [PDF]

BMC Musculoskelet Disord
Hu W, Nie Y, Li Y, Yang B, Su Z, Zhu Z, Xie C, Lin L.   +7 more
europepmc   +1 more source