Results 171 to 180 of about 9,354,588 (295)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Left atrial strain on 2D-STE in pediatric dilated cardiomyopathy. [PDF]

Echo Res Pract
Wu Y, Xu QQ, Liu W, Hou C, Wang H, Shen J, Sun YW, Gu PP, Si XY, Lv HT, Sun L, Ding YY.   +11 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Quantitative Guanidinium CEST-Based pH Mapping at 3 T in Healthy and Pathological Muscle. [PDF]

NMR Biomed
Henriet V, Baudin PY, Marty B, Lapert M, Reyngoudt H.   +4 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

From measurement to biomarker trajectories: platform-agnostic Z score analysis of serum NfL and GFAP in ocrelizumab-treated multiple sclerosis. [PDF]

J Neurol
Inojosa H, Masanneck L, Akgün K, Hagler R, Meuth SG, Otto C, Schindler P, Schulze-Bosse K, Kuhle J, Benkert P, Ruprecht K, Pawlitzki M, Ziemssen T.   +12 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Predictive value of complete blood cell count-based inflammatory markers for peritonitis risk in peritoneal dialysis patients: A multicenter cohort study. [PDF]

PLoS One
Li X, Qiu W, Xu Q, Wen Y, Wu X, Zhan X, Peng F, Wang X, Wu J, Su N, Feng X, Tang X, Zhou Q, Tian N.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of the clinical characteristics of patients with COVID-19-related deaths during the two epidemic periods in a tertiary hospital in Wuhan, China: A retrospective study. [PDF]

Medicine (Baltimore)
Ding JM, Li M, Shen MY, Han L, Du JB.
europepmc   +1 more source