Results 211 to 220 of about 9,354,588 (295)

A Value Framework for Contractor Selection

, 2006
Chen, Z, Shen, QP, Chung, KHJ, Kumaraswamy, MM, Ekambaram, P   +4 more
core  

Effect of Cervical Restorations on Periodontal Health: An Observational Cross-Sectional Study. [PDF]

Cureus
Ahmad MZ, Mittal N, Bhukal S, Deshmukh K, Deshmukh SS, Sankeshwari B, Vhanmane P.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Microbiome functional gene pathways are indicative of cognitive performance in older adults at risk for Alzheimer's disease. [PDF]

Gut Microbes
Zeamer AL, Lai Y, Loew E, Sanborn V, Tracy M, Jo C, Ferdinand D, Ward DV, Bhattarai SK, Drake J, McCormick BA, Bucci V, Haran JP.   +12 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Evaluation of growth hormone provocative tests in Egyptian children with growth hormone-related short stature. [PDF]

World J Exp Med
Ahmed AE, Hassan MH, Hamdan RS, Sakhr HM.   +3 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Rapid value learning reveals generalized and context-dependent codes in frontal cortex

Gutierrez E, Muller T, Butler J, Malalasekera WN, Hunt L, Veselic S, Kennerley S.   +6 more
europepmc   +1 more source

Accuracy of reduction and postoperative symmetry assessment of customized z-shaped miniplates versus conventional miniplates in mandibular fractures treatment: a randomized controlled clinical trial. [PDF]

BMC Oral Health
Abd El Hamid MA, El Mahallawy AS, Saber ME.   +2 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source