Results 81 to 90 of about 1,833,192 (248)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Thermal inactivation of Salmonella in chicken curry puff filling

The Microbe
This study explores the potential risk of Salmonella contamination in chicken curry puff filling, focusing on chicken as a high-risk ingredient during filling preparation.
Nur Amira Rosli, Nor Ainy Mahyudin, Nor-Khaizura Mahmud Ab Rashid, Jinap Selamat, Lizawati Mohamad Darwi, Rahim Khan   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Average Values of some Z-Parameters in a Random Set Partition [PDF]

The Electronic Journal of Combinatorics, 2011
We find exact and asymptotic formulas for the average values of several statistics on set partitions: of Carlitz's $q$-Stirling distributions, of the numbers of crossings in linear and circular representations of set partitions, of the numbers of overlappings and embracings, and of the numbers of occurrences of a 2-pattern.
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Magnitude of hydrological events and extremes using the Z value

Climate Risk Management
Several definitions of “extreme event” can be found in literature, and many agree that an extreme is a rare, high (or low) magnitude event, where the concepts of rarity and magnitude depend on the physical and temporal contexts.
Francesco Fiorillo, Guido Leone
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

SINGULAR VALUES AND FIXED POINTS OF FAMILY OF FUNCTION $z e^{z}/(e^{z}-1)$

International Journal of Apllied Mathematics, 2014
The aim of this paper is to study the singular values and fixed points of one parameter family of generating function, h (z) = ze z ez−1 , ∈ R\{0}, which arises from the generalized Bernoulli generating function, Apostol- Bernoulli generating function or Stirling generating function.
openaire   +1 more source