Results 11 to 20 of about 8,452 (211)
Managing Drug-Drug Interactions Involving the Non-Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and intestinal efflux by P‐glycoprotein (P‐gp).
Zhou Z +6 more
europepmc +2 more sources
Effects of Cimetidine and Dolutegravir on the Endogenous Drug-Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers. [PDF]
Clin Pharmacol TherThis study was designed to assess the quantitative performance of endogenous drug–drug interaction (DDI) biomarkers (N1‐methylnicotinamide (1‐NMN), N1‐methyladenosine (m1A), and creatinine) for the organic cation transporters, OCT2 and MATE1/2K in the kidney.
Koishikawa T +17 more
europepmc +2 more sources
Climate warming promotes growth in Himalayan alpine cushion plants but threatens survival through increased extreme snowfall. [PDF]
New PhytolSummary Climate warming stimulates growth and reproduction in cold‐adapted plants but also leads to extreme weather events that may hinder their performance. We examined these predictions in the cold‐arid Himalayan subnival zone at 5900 m, where unprecedented warming and extreme snowfalls occurred over the past three decades.
Jandova V +6 more
europepmc +2 more sources
Zamek w Trembowli w świetle inwentarzy z lat 1550 i 1551
Acta Universitatis Lodziensis: Folia Historica, 2022 Artykuł dotyczy zamku w Trembowli (obecnie Ukraina) po przebudowie, jaką przeszedł w latach trzydziestych XVI w. z inicjatywy starosty Andrzeja Tęczyńskiego. Dotychczas znany był opis tej twierdzy zawarty w inwentarzu starostwa trembowelskiego z 1551 r.
Tadeusz Grabarczyk
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ZABEZPIECZENIE I EKSPOZYCJA MURÓW ZAMKU W CZŁUCHOWIE - DOŚWIADCZENIA I NOWE PROBLEMY
Ochrona Dziedzictwa Kulturowego, 2018 Zamek krzyżacki w Człuchowie (Schlochau, 1325-1365) był typowym zamkowym grodem klasztornym. Składał się z kwadratowego dziedzińca z krużgankiem, czterema skrzydłami i wolno stojącą wieżą. Zamek otoczał wąski zewnętrzny dziedziniec oraz fosa.
Grzegorz Bukal
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WAWEL W POLSKIM SYSTEMIE SŁUŻB KONSERWATORSKICH
Ochrona Dziedzictwa Kulturowego, 2016 The article describes the system of historic preservation care provided to the architectural complex of outstanding historical value located on the Wawel Hill.
Piotr M. Stępień
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Darwin's ‘mystery of mysteries’: the role of sexual selection in plant speciation
Biological Reviews, Volume 98, Issue 6, Page 1928-1944, December 2023., 2023 ABSTRACT Sexual selection is considered one of the key processes that contribute to the emergence of new species. While the connection between sexual selection and speciation has been supported by comparative studies, the mechanisms that mediate this connection remain unresolved, especially in plants. Similarly, it is not clear how speciation processes
Mohammadjavad Haghighatnia +3 more
wiley +1 more source
Kwartalnik Historii Kultury Materialnej, 2021 W artykule zaprezentowano nieznane dotąd w literaturze naukowej założenie obronno-rezydencjonalne znajdujące się w miejscowości Wilczyska, w obecnym woj. lubelskim.
Wojciech Bis
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New Phytologist, Volume 240, Issue 5, Page 2151-2163, December 2023., 2023 Summary Arbuscular mycorrhizal (AM) fungi are crucial mutualistic symbionts of the majority of plant species, with essential roles in plant nutrient uptake and stress mitigation. The importance of AM fungi in ecosystems contrasts with our limited understanding of the patterns of AM fungal biogeography and the environmental factors that drive those ...
Tomáš Větrovský +24 more
wiley +1 more source