ZAP-70: aspectos práticos ZAP-70: practical aspects [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2005 A ZAP-70 é uma proteína kinase normalmente expressa nos linfócitos T e células NK, mas ausente nos linfócitos B. No entanto, ela está expressa nas células B de pacientes com LLC que não apresentam mutação nos genes da região variável da cadeia pesada de ...
Mihoko Yamamoto
doaj +9 more sources
T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival. [PDF]
PLoS ONE, 2022 B-cell receptor (BCR) signalling is critical for the survival of B-cell lymphomas and is a therapeutic target of drugs such as Ibrutinib. However, the role of T-cell receptor (TCR) signalling in the survival of T/Natural Killer (NK) lymphomas is not ...
Sanjay de Mel +16 more
doaj +2 more sources
Two patients with ZAP-70 deficiency in China present with a different genetic, immunological, and clinical phenotype [PDF]
BMC Pediatrics, 2023 Zeta(ζ)-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare autosomal recessive primary immunodeficiency disease. Little is known about this disease.
Xianze Luo +5 more
doaj +2 more sources
ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies [PDF]
Frontiers in Oncology, 2020 Zeta-chain-associated protein kinase-70 (ZAP-70) is a tyrosine kinase mainly expressed in T cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation through its tyrosine kinase activity.
Jingyu Chen +2 more
doaj +2 more sources
Protein clusters on the T cell surface may suppress spurious early signaling events. [PDF]
PLoS ONE, 2012 T cells play an important role in the adaptive immune system, quickly activating effector functions in response to small numbers of antigenic peptides but rarely activating in response to constant interaction with most endogenous peptides.
Woo Chung +2 more
doaj +12 more sources
Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review [PDF]
Frontiers in Immunology, 2020 Background: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare combined immunodeficiency (CID) caused by recessive homozygous/compound heterozygous loss-of-function mutations in the ZAP70 gene.
Niusha Sharifinejad +16 more
doaj +2 more sources
Novel ZAP-70-Related Immunodeficiency Presenting with Epstein–Barr Virus Lymphoproliferative Disorder and Hemophagocytic Lymphohistiocytosis [PDF]
Case Reports in Immunology, 2021 Zeta-chain-associated protein kinase 70 (ZAP-70) plays an integral role in the T-cell antigenic receptor complex. A deficiency of this kinase leads to a phenotype of severe combined immunodeficiency, while hypomorphic mutations of the kinase lead to more
Moriah Forster +3 more
doaj +2 more sources
Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia [PDF]
BMC Research Notes, 2019 Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation.
Ameen Abdulaziz Basabaeen +9 more
doaj +2 more sources
ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis [PDF]
Cells, 2019 T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the ...
Réka Kugyelka +7 more
doaj +2 more sources
ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study [PDF]
Hematology, Transfusion and Cell Therapy, 2018 Background: Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells ...
Rodolfo Patussi Correia +5 more
doaj +2 more sources