ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies [PDF]
Frontiers in Oncology, 2020 Zeta-chain-associated protein kinase-70 (ZAP-70) is a tyrosine kinase mainly expressed in T cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation through its tyrosine kinase activity.
Jingyu Chen +2 more
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T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival. [PDF]
PLoS ONE, 2022 B-cell receptor (BCR) signalling is critical for the survival of B-cell lymphomas and is a therapeutic target of drugs such as Ibrutinib. However, the role of T-cell receptor (TCR) signalling in the survival of T/Natural Killer (NK) lymphomas is not ...
Sanjay de Mel +16 more
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Two patients with ZAP-70 deficiency in China present with a different genetic, immunological, and clinical phenotype [PDF]
BMC Pediatrics, 2023 Zeta(ζ)-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare autosomal recessive primary immunodeficiency disease. Little is known about this disease.
Xianze Luo +5 more
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Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review [PDF]
Frontiers in Immunology, 2020 Background: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare combined immunodeficiency (CID) caused by recessive homozygous/compound heterozygous loss-of-function mutations in the ZAP70 gene.
Niusha Sharifinejad +16 more
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Novel ZAP-70-Related Immunodeficiency Presenting with Epstein–Barr Virus Lymphoproliferative Disorder and Hemophagocytic Lymphohistiocytosis [PDF]
Case Reports in Immunology, 2021 Zeta-chain-associated protein kinase 70 (ZAP-70) plays an integral role in the T-cell antigenic receptor complex. A deficiency of this kinase leads to a phenotype of severe combined immunodeficiency, while hypomorphic mutations of the kinase lead to more
Moriah Forster +3 more
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Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia [PDF]
BMC Research Notes, 2019 Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation.
Ameen Abdulaziz Basabaeen +9 more
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ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis [PDF]
Cells, 2019 T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the ...
Réka Kugyelka +7 more
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ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study [PDF]
Hematology, Transfusion and Cell Therapy, 2018 Background: Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells ...
Rodolfo Patussi Correia +5 more
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The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain. [PDF]
PLoS Computational Biology, 2015 ZAP-70 (Zeta-chain-associated protein kinase 70) is a tyrosine kinase that interacts directly with the activated T-cell receptor to transduce downstream signals, and is hence a major player in the regulation of the adaptive immune response.
Roland G Huber, Hao Fan, Peter J Bond
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Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70 [PDF]
Molecules, 2019 A variety of natural compounds have been shown to modulate T cell receptor (TCR) activation, including natural sesquiterpene lactones (SLs). In the present studies, we evaluated the biological activity of 11 novel semi-synthetic SLs to determine their ...
Andrei I. Khlebnikov +7 more
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