Results 191 to 200 of about 419,255 (408)
Development of the retinotectal projection in zebrafish embryos under TTX-induced neural-impulse blockade [PDF]
, 1990 CA Stuermer +2 more
openalex +1 more source
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
Angewandte Chemie, EarlyView.A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth +9 more
wiley +2 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The interstitial 6p microdeletion syndrome is characterized by dysmorphic facies and structural heart, kidney, brain, and musculoskeletal differences. RREB1 haploinsufficiency and consequent abnormal RAS‐MAPK pathway signaling have been proposed as a driver of the disease phenotype; however, apart from a single case report, the phenotype of ...
Alanna Strong +16 more
wiley +1 more source
Lethal toxicity of metformin on zebrafish during early embryonic development by multi-omics analysis
Scientific ReportsMetformin is an antidiabetic drug used in type 2 diabetes as well as indicators in polycystic ovary syndrome (PCOS) and cancer. Due to their increase in popularity, high amounts of metformin are being released into aquatic environments.
Ziyuan Lin +5 more
doaj +1 more source
Information of Epileptic Mechanism and its Systemic Change-points in a Zebrafish's Brain-wide Calcium Imaging Video Data [PDF]
arXiv, 2018 The epileptic mechanism is postulated as that an animal's neurons gradually diminish their inhibition function coupled with enhanced excitation when an epileptic event is approaching. Calcium imaging technique is designed to directly record brain-wide neurons activity in order to discover the underlying epileptic mechanism.
arxiv
A pioneering growth cone in the embryonic zebrafish brain. [PDF]
, 1991 Stephen W. Wilson, Stephen S. Easter
openalex +1 more source
Angewandte Chemie, EarlyView.A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao +7 more
wiley +2 more sources
Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage [PDF]
, 1996 The appearance of the embryonic shield, a slight thickening at the leading edge of the blastoderm during the formation of the germ ring, is one of the first signs of dorsoventral polarity in the zebrafish embryo.
Fraser, Scott E., Shih, John
core
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp +7 more
wiley +1 more source
Towards Precision Cardiovascular Analysis in Zebrafish: The ZACAF Paradigm [PDF]
arXivQuantifying cardiovascular parameters like ejection fraction in zebrafish as a host of biological investigations has been extensively studied. Since current manual monitoring techniques are time-consuming and fallible, several image processing frameworks have been proposed to automate the process.
arxiv