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Zebrafish as a Cancer Model [PDF]
Molecular Cancer Research, 2008 Abstract The zebrafish has developed into an important model organism for biomedical research over the last decades. Although the main focus of zebrafish research has traditionally been on developmental biology, keeping and observing zebrafish in the lab led to the identification of diseases similar to humans, such as cancer, which ...
Harma Feitsma, Edwin Cuppen
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Zebrafish, 2006
Zebrafish (Danio rerio), a small prolific rapidly-developing diurnal vertebrate, shows behavioral, physiological, and pharmacological characteristics of mammalian sleep. Zebrafish brain has well-developed neuronal structures and neurochemical systems that are known to be necessary and sufficient for sleep regulation in other vertebrate species.
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Zebrafish (Danio rerio), a small prolific rapidly-developing diurnal vertebrate, shows behavioral, physiological, and pharmacological characteristics of mammalian sleep. Zebrafish brain has well-developed neuronal structures and neurochemical systems that are known to be necessary and sufficient for sleep regulation in other vertebrate species.
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2016
In vivo models of Rhabdomyosarcoma (RMS) have proven instrumental in understanding the development and progression of this devastating pediatric sarcoma. Both vertebrate and invertebrate model systems have been developed to study the tumor biology of both embryonal (ERMS) and alveolar (ARMS) RMS subtypes.
Michael, Phelps, Eleanor, Chen
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In vivo models of Rhabdomyosarcoma (RMS) have proven instrumental in understanding the development and progression of this devastating pediatric sarcoma. Both vertebrate and invertebrate model systems have been developed to study the tumor biology of both embryonal (ERMS) and alveolar (ARMS) RMS subtypes.
Michael, Phelps, Eleanor, Chen
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Zebrafish: An emerging model system to study liver diseases and related drug discovery
Journal of Applied Toxicology, 2020The zebrafish has emerged as a powerful vertebrate model for studying liver‐associated disorders. Liver damage is a crucial problem in the process of drug development and zebrafish have proven to be an important tool for the high‐throughput screening of ...
Swati Katoch, V. Patial
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Toxicological study of metal and metal oxide nanoparticles in zebrafish
Journal of Applied Toxicology, 2019Metal and metal oxide nanoparticles have been widely used in catalytic, electronic and biomedical fields. It is necessary to investigate their toxicity and potential hazards to human and aquatic ecosystems.
Changcun Bai, M. Tang
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2016
The generation and use of transgenic animals carrying exogenous pieces of DNA stably integrated in their genome is a quite common practice in modern laboratories. Zebrafish have been increasingly used for transgenesis studies mainly due to easy egg accessibility and manipulation together with relatively short generation time.
Xiaowen, Chen +2 more
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The generation and use of transgenic animals carrying exogenous pieces of DNA stably integrated in their genome is a quite common practice in modern laboratories. Zebrafish have been increasingly used for transgenesis studies mainly due to easy egg accessibility and manipulation together with relatively short generation time.
Xiaowen, Chen +2 more
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1999
Both genetic and embryological studies in the zebrafish, Danio rerio, have contributed to our general understanding of how somites form and differentiate. In the zebrafish, mutants have been isolated that have specific effects on virtually every aspect of somite development.
Christiane Nüsslein-Volhard +1 more
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Both genetic and embryological studies in the zebrafish, Danio rerio, have contributed to our general understanding of how somites form and differentiate. In the zebrafish, mutants have been isolated that have specific effects on virtually every aspect of somite development.
Christiane Nüsslein-Volhard +1 more
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2013
Zebrafish are ideally suited for analysis of genes required for ciliogenesis and cilia function. Combining genetic manipulation with high quality in vivo imaging, zebrafish embryos provide a high-throughput system for annotation of the cilia proteome.
Iain A. Drummond, Christina Austin-Tse
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Zebrafish are ideally suited for analysis of genes required for ciliogenesis and cilia function. Combining genetic manipulation with high quality in vivo imaging, zebrafish embryos provide a high-throughput system for annotation of the cilia proteome.
Iain A. Drummond, Christina Austin-Tse
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2016
Melanoma skin cancer is a potentially deadly disease in humans and has remained extremely difficult to treat once it has metastasized. In just the last 10 years, a number of models of melanoma have been developed in the zebrafish that are biologically faithful to the human disease and have already yielded important insights into the fundamental biology
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Melanoma skin cancer is a potentially deadly disease in humans and has remained extremely difficult to treat once it has metastasized. In just the last 10 years, a number of models of melanoma have been developed in the zebrafish that are biologically faithful to the human disease and have already yielded important insights into the fundamental biology
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