Results 81 to 90 of about 82,713 (302)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Addressing the Plight of Poor Households by Zero-Rating VAT on Basic Commodities in Namibia [PDF]
Though it is classified as an upper middle-income country and has an estimated annual gross national income (GNI) per capita of US$4,210, Namibia still faces the twin problems of relatively high levels of poverty and high income inequality.
John E. Odada, Ojijo Odhiambo
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Review of the strengths and weaknesses of risk matrices [PDF]
, 2014 Risk assessment and risk matrices are powered tools used in risk management and help guide in the process of decision-making in organisations. Nevertheless, risk matrices have their own weaknesses and strengths. This paper provides a critical overview of
Elmontsri, M
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Revista de Defesa da Concorrência, 2016 O presente artigo analisa a interface entre a neutralidade de rede e o Direito da Concorrência, tomando como base os acordos de zero-rating. Para explorar melhor os impactos da neutralidade de rede em modelos de negócio que envolvem a internet, o objeto
Leandro Novais e Silva +2 more
doaj
Effectiveness of the Primextra Gold in controlling weeds of Cucumber (Cucumis Sativus L.)
Journal of Applied Sciences and Environmental Management, 2016 The efficacy of Primextra Gold herbicide in controlling weeds in cucumber was evaluated in this research. The experiment was laid out in a randomized complete block design with four replications. Seven weed control treatments – 0.0, 0.25, 0.5, 0.75, 1.0,
RU Ogwunna, EB Ochekwu, DI Anyanwu
doaj +1 more source
Pricing and Revenue Sharing between ISPs under Content Sharing [PDF]
, 2018 Department of Electrical EngineeringAs sponsored data with subsidized access cost gains popularity in industry, it is essential to understand its impact on the Internet service market. We investigate the interplay among Internet Service Providers (ISPs),
Satybaldy, Abylay
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