Results 61 to 70 of about 5,298,675 (236)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

A voltage detection method based on dq transformation and symmetric component method

open access: yesGong-kuang zidonghua, 2018
In view of problem that fault type and phase of asymmetric voltage sag could not be quickly identified by traditional voltage sag detection algorithm, a voltage detection method based on dq transformation and symmetric component method was proposed ...
WANG Jianyu
doaj   +1 more source

Uncertain Zero-One Law and Convergence of Uncertain Sequence [PDF]

open access: yes, 2016
This paper is concerned with situations in which the uncertain measure of an event can only be zero or one, and the uncertain zero-one laws are derived within the framework of uncertainty theory that can be seen as the counterpart of Kolmogorov zero-one ...
Zhiqiang Zhang, Xiumei Chen, Weiqi Liu
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Bayesian zero-failure reliability demonstration [PDF]

open access: yes, 2005
We study required numbers of tasks to be tested for a technical system, including systems with built-in redundancy, in order to demonstrate its reliability with regard to its use in a process after testing, where the system has to function for different ...
Rahrouh, Maha
core  

Modeling of PMSMs Considering Spatial Harmonics, Interturn Short-Circuit Faults, and Zero-Sequence Components

open access: yesIEEE Transactions on Industry Applications
This paper presents a rotor-position dependent (RPD) model for permanent-magnet synchronous machines (surface-mounted or interior permanent-magnet) considering both space harmonics, interturn short-circuit faults and zero-sequence components. First, the healthy machine model is obtained.
Geoffrey Postal   +2 more
openaire   +2 more sources

Is Our Carbon Wallet Empty: The embodied carbon of the national infrastructure pipeline. A report by the Net Zero Infrastructure Industry Coalition

open access: yes, 2021
This report highlights the challenges the infrastructure sector faces in addressing the UK’s net-zero carbon commitment by 2050. Included is a manifesto for change, which will enable the infrastructure sector to measure, control and reduce carbon ...
Net Zero Infrastructure Industry Coalition
core   +1 more source

Control Strategies for Open-End Winding Drives Operating in the Flux-Weakening Region [PDF]

open access: yes, 2013
This paper presents and compares control strategies for three-phase open-end winding drives operating in the flux-weakening region. A six-leg inverter with a single dc-link is associated with the machine in order to use a single energy source.
KESTELYN, Xavier   +4 more
core   +1 more source

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