Results 81 to 90 of about 5,296,797 (286)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Capturing the Zero: A New Class of Zero-Augmented Distributions and Multiplicative Error Processes [PDF]

We propose a novel approach to model serially dependent positive-valued variables which realize a non-trivial proportion of zero outcomes. This is a typical phenomenon in financial time series observed on high frequencies, such as cumulated trading ...
Peter Malec, Nikolaus Hautsch, Melanie Schienle   +2 more
core  

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Online capacity detection of distribution transformers based on zero-sequence impedance curve matching

Frontiers in Energy Research
Unauthorized tampering with distribution transformer nameplates poses significant economic and operational risks to power utilities, while conventional offline capacity detection methods require power outages and existing online short-circuit impedance ...
Bo Li, Yu-Xing Lei, Meng-Meng Zhu, Yao-Hua Liao, Ren-Jie Guo, Ming-Gui Yang, Xin-Dong Zhang   +6 more
doaj   +1 more source

Research on the Neutral-Point Voltage Balance for NPC Three-Level Inverters under Non-Ideal Grid Conditions

Energies, 2018
In order to solve the neutral-point voltage unbalancing problem for neutral-point clamped (NPC) three-level inverters under non-ideal grid conditions, a novel zero-sequence component injection method for modulation signals was proposed in this paper ...
Jian Guo Lyu, Ji Dong Wang, Wen Bin Hu, Zhao Feng Wu   +3 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

On the number of Smarandache zero-divisors and Smarandache weak zero-divisors in loop rings [PDF]

, 2005
Finding the number of Smarandache zero divisors (S-zero divisors) and Smarandache weak zero divisors (S-weak zero divisors) for the loop ...
Chetry, K. Moon, Vasantha, W.B.
core   +1 more source

Line Selection Device of Small Current Single-phase Grounding Fault Based on Integrative Line Selection Strategy

Gong-kuang zidonghua, 2012
For the deficiency of single line selection principle, the paper proposed integrative line selection strategy, namely zero sequence admittance method, zero sequence susceptance increment method and zero sequence conductance method based on steady-state ...
LI Hui, TANG Yi, SUN Chang-qing
doaj