Results 61 to 70 of about 5,304,242 (286)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Homo academicus: LGBTI and queer studies in Spain

, 2010
En la década de los 2000, España ha experimentado significativos cambios sociales y legales en relación con la comunidad LGBTI, y esto comenzó a reflejarse en el ámbito académico, especialmente en universidades e investigación.
Pichardo Galán, José Ignacio
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Direct Power Control of Vienna Rectifier Based on Fractional Order Sliding Mode Control

World Electric Vehicle Journal
Taking a Vienna rectifier as the research object, the power mathematical model based on a switching function is established according to its working principle.
Tao Wang, Shenhui Chen, Xin Li, Jihui Zhang, Jinghao Ma   +4 more
doaj   +1 more source

Research on the Equivalent Virtual Space Vector Modulation Output of Diode Clamped N-level Converter under Multi-Modulation Carrier Modulation

Energies, 2020
Diode-clamped multi-level converters have DC-side capacitors in series, which will lead to the unbalance of DC-side capacitor voltage, the distortion of the output waveform, the increase of total harmonic distortion (THD), and even the damage of ...
Yingjie He, Chao Lei, Yunfeng Liu, Jinjun Liu   +3 more
doaj   +1 more source

Advanced Microgrid Protection Utilizing Zero Sequence Components With Hard-Ware-in-the-Loop Testing

IEEE Access
Microgrid protection and ground fault management are critical aspects of modern power distribution systems, especially with the increasing integration of Distributed Generators (DGs) such as renewable energy sources. Effective protection schemes are essential to ensure the reliability, safety, and resilience of microgrids under various fault conditions.
Zahra Ghanem, Feras Alasali, Naser El-Naily, Hassen Loukil, Haytham Y. Mustafa, Saad M. Saad, Abdelaziz Salah Saidi, William Holderbaum   +7 more
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Fast Multilevel SVPWM Method Based on the Imaginary Coordinate With Direct Control of Redundant Vectors or Zero Sequence Components

IEEE Open Journal of the Industrial Electronics Society, 2020
This paper for the first time comprehensively presents a multilevel space vector pulse width modulation (SVPWM) method based on the imaginary coordinate system. This method is probably one of the most efficient methods in fast multilevel SVPWMs.
Xibo Yuan, Yue Gao, Yongdong Li
doaj   +1 more source

Two-component signalling systems of chloroplasts: function, distribution and evolution [PDF]

, 2008
PhD 2008 QMTwo-component signal transduction, comprising sensor kinases and response regulators, is the predominant signalling mechanism in prokaryotes.
Puthiyaveetil, Sujith
core   +4 more sources