Results 31 to 40 of about 183,908 (257)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Gong-kuang zidonghua, 2012 For problem of ineffectiveness of traditional line selection methods by use of single feature value caused by complex and random fault borderline, small steady component of fault and reverse phase of instantaneous zero-sequence power when single-phase ...
TIAN Shu, HE Jin-peng, NIE He
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Kongzhi Yu Xinxi Jishu, 2013 This paper illustrated var and negative sequence comprehensive compensation principles of cascaded static var generator(SVG) with star-configuration. The mathematical expression of zero-sequence voltage was deduced, and subsequently zero-sequence voltage
XIONG Qiaopo, LUO An, ZENG Zhizhen
doaj
Fuzzy comprehensive line selection method of resonance grounding fault in coal mine
Gong-kuang zidonghua, 2015 For failure of fault line selection methods based on steady-state component in resonance grounding system, three kinds of methods were analyzed from the perspective of transient component including zero-sequence energy method, wavelet transform method ...
MA Chunyan, GONG Ying
doaj +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Energies, 2020 Diode-clamped multi-level converters have DC-side capacitors in series, which will lead to the unbalance of DC-side capacitor voltage, the distortion of the output waveform, the increase of total harmonic distortion (THD), and even the damage of ...
Yingjie He +3 more
doaj +1 more source