Results 51 to 60 of about 5,296,797 (286)

Bayesian zero-failure reliability demonstration [PDF]

, 2005
We study required numbers of tasks to be tested for a technical system, including systems with built-in redundancy, in order to demonstrate its reliability with regard to its use in a process after testing, where the system has to function for different ...
Rahrouh, Maha
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Homo academicus: LGBTI and queer studies in Spain

, 2010
En la década de los 2000, España ha experimentado significativos cambios sociales y legales en relación con la comunidad LGBTI, y esto comenzó a reflejarse en el ámbito académico, especialmente en universidades e investigación.
Pichardo Galán, José Ignacio
core   +1 more source

Advanced Microgrid Protection Utilizing Zero Sequence Components With Hard-Ware-in-the-Loop Testing

IEEE Access
Microgrid protection and ground fault management are critical aspects of modern power distribution systems, especially with the increasing integration of Distributed Generators (DGs) such as renewable energy sources. Effective protection schemes are essential to ensure the reliability, safety, and resilience of microgrids under various fault conditions.
Zahra Ghanem, Feras Alasali, Naser El-Naily, Hassen Loukil, Haytham Y. Mustafa, Saad M. Saad, Abdelaziz Salah Saidi, William Holderbaum   +7 more
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Research on single-phase grounding characteristics of low-resistance grounding systems with distributed generation

International Journal of Electrical Power & Energy Systems
The network-level characteristics of zero-sequence currents during single-phase ground faults in existing low-resistance grounding systems with inverter-interfaced distributed generators (IIDGs) remain unclear. Moreover, the influence of IIDG integration
Jianwen Zhao, Fuyang Zeng
doaj   +1 more source

Research on the Equivalent Virtual Space Vector Modulation Output of Diode Clamped N-level Converter under Multi-Modulation Carrier Modulation

Energies, 2020
Diode-clamped multi-level converters have DC-side capacitors in series, which will lead to the unbalance of DC-side capacitor voltage, the distortion of the output waveform, the increase of total harmonic distortion (THD), and even the damage of ...
Yingjie He, Chao Lei, Yunfeng Liu, Jinjun Liu   +3 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Two-component signalling systems of chloroplasts: function, distribution and evolution [PDF]

, 2008
PhD 2008 QMTwo-component signal transduction, comprising sensor kinases and response regulators, is the predominant signalling mechanism in prokaryotes.
Puthiyaveetil, Sujith
core   +4 more sources