Results 71 to 80 of about 5,589,178 (285)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

open access: yesMolecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński   +12 more
wiley   +1 more source

A voltage detection method based on dq transformation and symmetric component method

open access: yesGong-kuang zidonghua, 2018
In view of problem that fault type and phase of asymmetric voltage sag could not be quickly identified by traditional voltage sag detection algorithm, a voltage detection method based on dq transformation and symmetric component method was proposed ...
WANG Jianyu
doaj   +1 more source

Domain-Aware Continual Zero-Shot Learning

open access: yes, 2021
We introduce Domain Aware Continual Zero-Shot Learning (DACZSL), the task of visually recognizing images of unseen categories in unseen domains sequentially. We created DACZSL on top of the DomainNet dataset by dividing it into a sequence of tasks, where
Yi, Kai
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Bayesian zero-failure reliability demonstration [PDF]

open access: yes, 2005
We study required numbers of tasks to be tested for a technical system, including systems with built-in redundancy, in order to demonstrate its reliability with regard to its use in a process after testing, where the system has to function for different ...
Rahrouh, Maha
core  

Modeling of PMSMs Considering Spatial Harmonics, Interturn Short-Circuit Faults, and Zero-Sequence Components

open access: yesIEEE Transactions on Industry Applications
This paper presents a rotor-position dependent (RPD) model for permanent-magnet synchronous machines (surface-mounted or interior permanent-magnet) considering both space harmonics, interturn short-circuit faults and zero-sequence components. First, the healthy machine model is obtained.
Geoffrey Postal   +2 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Is Our Carbon Wallet Empty: The embodied carbon of the national infrastructure pipeline. A report by the Net Zero Infrastructure Industry Coalition

open access: yes, 2021
This report highlights the challenges the infrastructure sector faces in addressing the UK’s net-zero carbon commitment by 2050. Included is a manifesto for change, which will enable the infrastructure sector to measure, control and reduce carbon ...
Net Zero Infrastructure Industry Coalition
core   +1 more source

NETWORK-CENTRIC TECHNOLOGIES FOR CONTROL OF THREE-PHASE NETWORK OPERATION MODES

open access: yesElectrical engineering & Electromechanics, 2017
Purpose. The development of the control system for three-phase network is based on intelligent technologies of network-centric control of heterogeneous objects.
Ye. I. Sokol   +5 more
doaj   +1 more source

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