Microwave‐Assisted, One‐Pot Three Component Synthesis of 2‐Phenyl H‐imidazo[1,2‐α]pyridine [PDF]
Journal of Chemistry, Volume 9, Issue 3, Page 1047-1052, 2012., 2012 A novel synthesis of 2‐phenylH‐imidazio[1,2‐α] pyridines is described from a one‐pot, three‐component reaction between pyridine, guanidine (urea or thiourea) and α‐bromoketones under microwave irradiation and solvent‐free conditions in excellent yields.
Kourosh Motevalli +2 more
wiley +4 more sources
Zolimidine Analogues: The Synthesis of Imidazo[1,2-α]pyridine-Based Sulfilimines and Sulfoximines
Synthesis, 2015 Zolimidine is a methylsulfonyl-substituted drug with an imidazo[1,2-α]pyridine core used for the treatment of peptic ulcer. Herein, we report the synthesis of unprecedented N-acetylsulfilimine and -sulfoximine analogues under mild conditions. Deprotection of the N-acetylsulfoximine allows the preparation of the corresponding NH-sulfoximine.
Carsten Bolm +2 more
+13 more sources
Ruthenium-Catalyzed Monoselective C-H Methylation and d 3-Methylation of Arenes. [PDF]
JACS Au, 2022 [Image: see text] Site-selective installation of C–Me bonds remains a powerful and sought-after tool to alter the chemical and pharmacological properties of a molecule.
Hogg A +5 more
europepmc +3 more sources
Mechanochemical Strategies Applied to the Late-Stage Modifications of Pharmaceutically Active Compounds. [PDF]
Angew Chem Int Ed EnglThis review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Templ J, Borchardt L.
europepmc +2 more sources
Sustainable Mechanosynthesis of Biologically Active Molecules
European Journal of Organic Chemistry, Volume 2022, Issue 21, June 7, 2022., 2022 Mechanochemistry contributes to the sustainable preparation of molecules in many areas of chemistry. This Review focuses on the mechanosynthesis of known APIs and biologically evaluated new entities (medicinal mechanochemistry), mostly heterocycles, metal complexes, and peptides. Abstract Synthetic mechanochemistry, the use of mechanical force produced
Ophélie Bento +5 more
wiley +1 more source
Biomedical and Biochemical Approaches and Strategies for Targeting and Delivery of Cadmium Oxide (CdO) Nanoparticles Aggregation Linked to DNA/RNA by Aryl Mercaptanes with Various Chain Length [PDF]
, 2022 CdO nanoparticles show a strong peak of Plasmon absorption in ultraviolet-visible zone. A strong interaction exists between the surface of CdO nanoparticles and aryl mercaptan compounds.
Heidari, Alireza
core +3 more sources
Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals [PDF]
, 2018 Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained ...
Cronin, Leroy +6 more
core +1 more source
Synthetic transformation of 6-Fluoroimidazo[1,2-a]Pyridine-3-carbaldehyde into 6-Fluoroimidazo[1,2-a]Pyridine-Oxazole Derivatives: In vitro urease inhibition and in silico study [PDF]
, 2023 Purpose: Ulcer is a serious disease that is caused due to different bacteria and over usage of various NSAIDs which caused to reduce the defensive system of stomach. Therefore, some novel series are needed to overcome these issues. Methods: Oxazole-based
Alanazi, MM +7 more
core +1 more source
Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions [PDF]
, 2016 A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale).
A. John Blacker +54 more
core +1 more source
Fluorination methods in drug discovery [PDF]
, 2016 Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that the fluorine atom can impart ...
Bonesi, Sergio Mauricio +2 more
core +1 more source