Results 71 to 80 of about 18,826 (294)

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Apocalipse zombie, sem efeitos especiais

, 2020
A propósito do SARS-CoV-2/COVID-19, que apresento como zoonose contemporânea, discuto neste ensaio as articulações entre epidemias e memória coletiva, produção de conhecimento, literatura, arte, experiência vivida, medo, preparação e prevenção de ...
Bastos, Cristiana
core   +1 more source

“LIFE AFTER PEOPLE”: ZOMBIE APOCALYPSE AND THE STRUCTURES OF THE POST-HUMAN GLOBAL IMAGINARY

Studia Universitatis Babeş-Bolyai. Philologia, 2019
Life after People: Zombie Apocalypse and the Structures of the Post-Human Global Imaginary. The paper examines post-humanist representations in Anglo-American film productions from a perspective informed by global and hypermodern cultural theory.
Adriana NEAGU
doaj   +1 more source

Zombie, vous avez dit zombie ? Quand l’apocalypse zombie s’empare du roman

, 2013
Cet article examine la manière dont les genres littéraires narratifs (roman et nouvelle) se sont approprié la figure du zombie mythifiée au cinéma par George A. Romero.
Patrick Bergeron, Bergeron, Patrick
core   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

The Graves of Wrath: A Hypothesis on the Creation of the American Zombie

Ex-centric Narratives: Journal of Anglophone Literature, Culture and Media
While zombie scholars agree both that George Romero’s 1968 film Night of the Living Dead inaugurated the American zombie myth, and that the various manifestations of the zombie reflect the cultural anxieties of each age, this essay aspires to propose the
Christina Dokou
doaj   +1 more source

Undermining Authoritarianism: Retrofitting the Zombie in "Seminário dos ratos" by Lygia Fagundes Telles

Alambique, 2018
Although the figure of the zombie has proved to be quite popular in recent years in Brazil—thanks in large part to the wave of imported graphic novels, television shows, and movies—Brazilian literature does not possess a strong tradition of autochthonous
James R. Krause
doaj   +1 more source