Results 51 to 60 of about 18,236,560 (241)
Aquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
Girón MD +10 more
europepmc +2 more sources
SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer
Advanced Science, EarlyView.Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian +8 more
wiley +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
The Rise of the Zombie Viruses: The Hidden Danger of the Arctic Thaw
ExonThe Arctic permafrost, which covers a quarter of the northern hemisphere, contains ancient viruses and bacteria that have been frozen for millions of years.
Neelabh Datta, Kanchan Karmakar
doaj +1 more source
Advanced Science, EarlyView.This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang +15 more
wiley +1 more source
Pretty, Dead: Sociosexuality, Rationality and the Transition into Zom-Being [PDF]
, 2014 The undead have been evoked in philosophical hypotheses regarding consciousness, but such discussions often come across as abstract academic exercises, inapplicable to personal experience.
Jones, Steve
core
Who Wants to Live Forever? Living, Dying and Grieving in Our Digital Society
Social Sciences, 2015 Almost ubiquitous hardware technology, such as smart phones, ensures that social networking sites are part of users’ everyday norms and routines. However, some are now using these new communication technologies to deal with the issues of death, dying and
Debra J. Bassett
doaj +1 more source
Advanced Science, EarlyView.A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang +8 more
wiley +1 more source
The Minneapolis Zombie Pub Crawl: Community in Costume
, 2013 An ethnographic, media, and historical study of the Minneapolis Zombie Pub Crawl, this paper explores the community formed during the largest zombie costuming event in the ...
Kavanaugh, Sam Edward James
core +1 more source
Advanced Science, EarlyView.Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao +7 more
wiley +1 more source