Results 151 to 160 of about 234 (216)
HCV‐Specific T‐Cell Recovery After a Year of SVR Following DAA Therapy
ABSTRACT Direct‐acting antiviral (DAA) drugs lead to sustained virologic response (SVR) in almost all treated patients with chronic hepatitis C virus (HCV) infection. Despite this success, the long‐term effects of HCV clearance by DAA therapy on T‐cell‐mediated antiviral immunity remain unclear, particularly concerning the restoration of immune ...
Tetiana Pozniak +9 more
wiley +1 more source
Secure Decentralized Key Relaying via Random Walks in Dynamic Semi‐Trusted QKD Networks
Quantum Key Distribution (QKD) provides point‐to‐point, information‐theoretically secure session keys, but distance limitations require trusted relays between remote parties. Can quantum keys be relayed without trusting every intermediate node or depending on a central controller?
Sergejs Kozlovičs +3 more
wiley +1 more source
Lipid nanoparticle composition governs distinct cytokine programs through the interplay of ionizable and polyethylene glycol‐conjugated (PEGylated) lipids. In vitro profiling, design of experiments (DoE) modeling, and in vivo validation reveal how formulation can tune reactogenicity‐associated pathways, while transgene expression remains the strongest ...
Adam Alexander Walters +16 more
wiley +1 more source
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
wiley +1 more source
Abstract We investigate how the affordances of an online context shape the processes of social learning. Using a dataset of more than 11,000 posts from the fraud subdread on the dark web forum Dread, we examine how affordances of platform governance, connectivity, anonymity, invisibility, asynchronicity, and limited oversight influence the components ...
Fangzhou Wang, Timothy Dickinson
wiley +1 more source
Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes +11 more
wiley +1 more source
Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan +8 more
wiley +1 more source
Managed decline: Muddling through with the Sterling (dis)Agreements, 1968–74
Abstract How do policymakers manage the decline of an international currency? This paper revisits the view that the ‘Sterling Agreements’ of 1968–74 – bilateral contracts between the UK and sterling‐holding governments – marked a successful paradigm shift towards sterling's managed ‘retirement’.
Alan de Bromhead +3 more
wiley +1 more source
Medication Non‐Adherence in First Episode Psychosis: A Systematic Review
ABSTRACT Objective Despite the efficacy of antipsychotics, medication non‐adherence remains common among individuals with a First Episode of Psychosis (FEP). Methods A systematic review was conducted in accordance with the PRISMA 2020 guidelines to summarise the existing evidence base regarding the reasons, attitudes, and beliefs underlying both ...
James Hunt, Anna Georgiades
wiley +1 more source
ABSTRACT Interventions aimed at reducing restrictive practices are also designed to enhance the service experience in acute mental health units. However, people with experience of coercive engagement with these services are seldom involved as active contributors in evaluative research on interventions to reduce restrictive practices.
Esario IV Daguman +4 more
wiley +1 more source

