Multiscale zonation-resolved modeling of dose-dependent determinants of acetaminophen-induced liver injury [PDF]
Frontiers in PharmacologyIntroductionDrug-induced liver injury (DILI) is a major cause of morbidity and mortality and has an important impact on drug attrition. Recent guidelines from the FDA and previous research encourage the development of virtual twin in silico modeling as a
Debarshi Ghosh +6 more
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Zonation, Zonation, Zonation: The Real Estate of the Liver. [PDF]
Annu Rev PatholThe liver serves as a central hub for a diverse set of functions including metabolic homeostasis, detoxification, and protein synthesis. While appearing homogeneous, hepatocytes, the major workhorse in the liver, demonstrate spatial identity within the lobule, which in turn dictates gene and protein expression and, eventually, function.
Yasaka TM, Kim CK, Meadows V, Monga SP.
europepmc +3 more sources
Glucagon contributes to liver zonation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 SignificanceThe lobules are the functional units of the liver. They consist of 15–25 layers of hepatocytes with specialized metabolic functions and gene expression patterns relative to their position along the lobule, a phenomenon referred to as metabolic zonation.
Xiping Cheng +2 more
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Liver zonation, revisited [PDF]
Hepatology, 2022 Abstract The concept of hepatocyte functional zonation is well established, with differences in metabolism and xenobiotic processing determined by multiple factors including oxygen and nutrient levels across the hepatic lobule. However, recent advances in single‐cell genomics technologies, including single‐cell and nuclei RNA sequencing, and ...
Jasmin Paris, Neil C. Henderson
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Determination of groundwater recharge–discharge zone to support water resources in Galur–Lendah area, Indonesia [PDF]
Journal of Water and Land Development, 2023 The impact of changes in regional development along with the construction of Yogyakarta International Airport in Kulon Progo Regency may affect land use changes as the activities of the surrounding population.
T. Listyani R.A. +2 more
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Significance of Liver Zonation in Hepatocellular Carcinoma
Frontiers in Cell and Developmental Biology, 2022 Liver zonation is fundamental to normal liver function, and numerous studies have investigated the microstructure of normal liver lobules. However, only a few studies have explored the zonation signature in hepatocellular carcinoma (HCC).
Shizhe Yu +22 more
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Determination of Effective factors and Assessment of Landslide Susceptibility Using Random Forest and Artificial Neural Network in Doab Samsami Region, Chaharmahal va Bakhtiari Province [PDF]
پژوهشهای آبخیزداری, 2022 Nowadays, landslides are among the geological hazards that data mining methods based on machine learning have been developed to model and predict. This paper addresses the development of a landslide susceptibility assessment that uses machine learning ...
Kourosh Shirani, Reza Naderi Samani
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Prevalent endosymbiont zonation shapes the depth distributions of scleractinian coral species [PDF]
Royal Society Open Science, 2015 Bathymetric distributions of photosynthetic marine invertebrate species are relatively well studied, however the importance of symbiont zonation (i.e. hosting of distinct algal endosymbiont communities over depth) in determining these depth distributions
Pim Bongaerts +5 more
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The feasibility of ash and spruce forest plantations in the Northeast of Iran [PDF]
Environmental Resources Research, 2021 In the present study, the feasibility of planting ash (Fraxinus excelsior L.) and spruce (Picea abies L.) tree species was investigated for rehabilitation of the Toroq Watershed in the northeast of Iran. The estimated land suitability indices ranged from
A. Bagherzadeh +2 more
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The Entry Selection System in Indonesia’s Public High Schools: Quo vadis [PDF]
Law Reform: Jurnal Pembaharuan Hukum, 2023 The selection mechanism for students seeking admission into public high schools still leaves the question: is it going to solve problems or even worsen them?
Muhamad Dzadit Taqwa +2 more
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