Results 201 to 210 of about 11,237 (264)

Functional editing of the OTC locus by targeted integration with phenotype correction and restoration of endogenous expression patterns. [PDF]

Mol Ther
Ginn SL, Doroudian F, Christina S, Chan OPY, Lucas CW, Zhu E, Yang SF, Devanapalli B, Klein AH, Scott S, Vitale J, Cunningham SC, Liao SHY, Cabanes-Creus M, Lisowski L, Alexander IE.   +15 more
europepmc   +1 more source

Beyond Global Models: Mapping the Spatially Contingent Relationship Between Soil Sand Content and Woody Invasion. [PDF]

Life (Basel)
Sosa B, Romero D, Guerrero JC, Aranda M, Achkar M.   +4 more
europepmc   +1 more source

Spatial transcriptomics and single-nucleus RNA sequencing reveal rAAV2- and rAAV9-specific transduction signatures in the mouse liver. [PDF]

Gene Ther
Amberg B, Köchl F, Kumpesa N, Prasad M, Bochner F, Hernández-Obiols M, Otteneder MB, Stalder L, Shaffo F, Nowrouzi A, Markusic D, Haegel H, Xicluna R, Sultan M, Jacobsen B, Rottenberg S, Valdeolivas A, Schwalie PC, Hahn K.   +18 more
europepmc   +1 more source

SMURF: soft-segmentation for single-cell reconstruction and topological analysis of spatial transcriptomic data. [PDF]

Nat Commun
Guo J, Sarafinovska S, Hagenson RA, Valentine MC, Chen DY, McCoy Iv WH, Dougherty JD, Mitra RD, Muegge BD.   +8 more
europepmc   +1 more source

Synthesis of the miospore zonation and correlation of conodont, cephalopod and miospore zonations

, 1993
Higgs, Ken, Streel, Maurice
openaire   +1 more source

Zonation, Zonation, Zonation: The Real Estate of the Liver

Annual Review of Pathology: Mechanisms of Disease
The liver serves as a central hub for a diverse set of functions including metabolic homeostasis, detoxification, and protein synthesis. While appearing homogeneous, hepatocytes, the major workhorse in the liver, demonstrate spatial identity within the lobule, which in turn dictates gene and protein expression and, eventually, function.
Satdarshan P Monga, Tyler Yasaka
exaly   +3 more sources

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Zooming in on liver zonation

Hepatology, 2018
The liver is composed of approximately a million hepatic lobules, microscopic hexagonal units that are patterned together in a three dimensional vasculature. Blood filters from portal triad points into central vein points at the center of each hexagonal lobule (Fig. 1). The lobule consists of hepatocyte plates that carry a gradient of recently absorbed
Felmlee, Daniel J., Grun, Dominic, Baumert, Thomas F.   +2 more
openaire   +4 more sources

Glucagon contributes to liver zonation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The lobules are the functional units of the liver. They consist of 15–25 layers of hepatocytes with specialized metabolic functions and gene expression patterns relative to their position along the lobule, a phenomenon referred to as metabolic zonation.
Sun Kim, Xiping Cheng, Jesper Gromada
exaly   +3 more sources

Adrenocortical zonation and ACTH

Microscopy Research and Technique, 2003
AbstractThe clear morphological distinction between the cells of the different adrenocortical zones has attracted speculation and experiment to interpret their functions and the ways in which they are regulated. Considerable data have been produced in recent years that has benefited a fuller understanding of the processes of steroidogenesis and of cell
openaire   +2 more sources

Geometries of Mineral Zonation, the Characteristic Geometries of Mineral Zonation

Journal of the Virtual Explorer, 2004
A series of numerical experiments using the Elle simulation platform were designed to reproduce zonation patterns resulting from a variety of grain scale processes. Comparison of the patterns of zonation produced allows us to distinguish between mineral zonation arising from diffusion, grain boundary migration driven by surface energy reduction, grain ...
openaire   +1 more source