Results 91 to 100 of about 751,195 (373)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Purchasing Copy, Printing and Scanning Services in Zurich [PDF]

open access: yes, 2015
Zurich is the largest Swiss city with approximately 400,000 inhabitants and an annual public procurement budget of over 1.6 billion. Sustainability has been a specific target on the City's political agenda since 1998.

core  

Application of the Zoom Meeting Application in Online Learning During the Pandemic

open access: yesEducation Quarterly Reviews, 2021
In the midst of the Covid-19 pandemic outbreak, almost all Indonesians, including Bengkulu province, expect to experience the spike in positive cases of Covid-19, particularly in the Rejang Lebong Regency, resulting in many very significant changes in ...

semanticscholar   +1 more source

Zoom in, zoom out: Geographic scale and multinational activity [PDF]

open access: yesJournal of International Business Studies, 2018
IB scholars have long studied the multinational enterprise (MNE) and now recognize that its ability to capture value stems from its control of bottleneck assets. In contrast, economic geographers and regional scientists have largely focused their attention on the locations within which economic and business systems operate.
Lee Li   +5 more
openaire   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

EnterpriseAI: A Transformer-Based Framework for Cost Optimization and Process Enhancement in Enterprise Systems

open access: yesComputers
Coordination among multiple interdependent processes and stakeholders and the allocation of optimal resources make enterprise systems management a challenging process.
Shinoy Vengaramkode Bhaskaran
doaj   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

open access: yesFEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada   +3 more
wiley   +1 more source

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

open access: yesFEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper   +5 more
wiley   +1 more source

DIFFRACTING HYBRID DIDAKTIK – RELATIONAL, FLUID, AND FRAGMENTED DIGITAL WRITING TUTORING IN HIGHER EDUCATION

open access: yesDigital Culture & Education, 2023
The study contributes to the nascent digital academic writing tutoring field by applying posthuman thinking while investigating intimate socio-material relations during a participatory action research project. Due to the COVID-19 pandemic (2020–2021), on-
Charlotta Hilli, Sofia Jusslin
doaj  

Editorial: To zoom or not to zoom – that is the question [PDF]

open access: yesInternational Journal of Social Psychiatry, 2021
Sam Nishanth Gnanapragasam   +2 more
openaire   +4 more sources

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