Results 41 to 50 of about 139,509 (257)

What Happens Next?

open access: yesThe International Journal of Screendance, 2021
No abstract available.
Omari 'Motion' Carter
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

DIFFRACTING HYBRID DIDAKTIK – RELATIONAL, FLUID, AND FRAGMENTED DIGITAL WRITING TUTORING IN HIGHER EDUCATION

open access: yesDigital Culture & Education, 2023
The study contributes to the nascent digital academic writing tutoring field by applying posthuman thinking while investigating intimate socio-material relations during a participatory action research project. Due to the COVID-19 pandemic (2020–2021), on-
Charlotta Hilli, Sofia Jusslin
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

EnterpriseAI: A Transformer-Based Framework for Cost Optimization and Process Enhancement in Enterprise Systems

open access: yesComputers
Coordination among multiple interdependent processes and stakeholders and the allocation of optimal resources make enterprise systems management a challenging process.
Shinoy Vengaramkode Bhaskaran
doaj   +1 more source

Optimization Of Video Conference With Priority Features On The Mikrotik Router

open access: yesComputer Science, 2022
Munculnya standar baru yang harus dipenuhi oleh semua aktor. Akses mudah ke konferensi video memiliki banyak aspek positif yang akhirnya menjadi kebutuhan saat ini.
Eka Kusuma Pratama   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

From Zoom to Zoom. An evidential interpretation of The Shining [PDF]

open access: yesEssais, 2018
La genèse de Shining témoigne de la complexité d’un long processus de création qui semble avoir, en certains moments décisifs, bifurqué. Si l’idée de départ était d’adapter librement le roman de Stephen King tout en inscrivant pleinement le film dans la tradition d’un genre, le trajet de la production aura quelque peu dévoyé ce projet.
openaire   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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