Results 111 to 120 of about 52,113 (304)
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Molecular Diagnosis of Scrub Typhus: Sample and Timing Matter
ZoonosesObjective: Scrub typhus (ST) is an acute febrile illness caused by Orientia tsutsugamushi.
Nagarajan L Surya +5 more
doaj +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
ZoonosesDiagnosis of scrub typhus is difficult, because of its non-specific clinical features and a lack of reliable serological assays. This study assessed real time PCR detection of the 47 kDa gene along with routine IgM ELISA for confirmatory diagnosis of ...
Sara Chandy +6 more
doaj +1 more source
Pasteurella lipoprotein E interacts with host ABCF2 to facilitate adhesion and cell apoptosis
mLife, EarlyView.Abstract Pasteurella multocida can cause serious diseases in many animal species and humans, yet the mechanisms of its pathogenesis remain to be elucidated. In this study, we found that the lipoprotein E (PlpE) of P. multocida contributed to bacterial adhesion to host cells.
Yuyao Shang +8 more
wiley +1 more source
Oikos, EarlyView.The ecological and epidemiological consequences of species expanding into new areas are growing concomitantly with climate change. Those aiming to monitor species expanding in range must make optimal use of finite resources to deliver effective surveillance capable of detecting new incursions and range expansions.
Susanna Cant +9 more
wiley +1 more source
ZoonosesThis study was aimed at assessing the prevalence of infection with Blastocystis , an intestinal protozoan parasite, among school-aged children, and to identify associated risk factors.
Thiéry Ndong Mba +3 more
doaj +1 more source
People and Nature, EarlyView.Abstract Overexploitation of wildlife is pervasive in many tropical regions, and in addition to being a significant conservation and sustainability concern, it has received global attention given discussions over the origins of zoonotic disease outbreaks.
Franklin T. Simo +8 more
wiley +1 more source