Results 51 to 60 of about 267,402 (311)

Cost-effectiveness of chikungunya vaccination with the live attenuated vaccine in U.S. territories

npj Vaccines
A live attenuated chikungunya vaccine, IXCHIQ, was approved in the United States in 2023 for use in adults. We assessed the cost-effectiveness of two different vaccination strategies, routine and outbreak vaccination, for persons aged ≥18 years living in
Kelly Kilburn, Martin I. Meltzer, Seonghye Jeon, Bishwa B. Adhikari, Nicole Lindsey, Susan L. Hills, J. Erin Staples   +6 more
doaj   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Epidemiology, impact and control of bovine cysticercosis in Europe : a systematic review [PDF]

, 2016
Background: Bovine cysticercosis in Europe has been known for centuries but the data showing the occurrence of this zoonosis are scarce. The aim of this paper is to review and present the current knowledge on bovine cysticercosis in Europe.
Allepuz, Alberto, Devleesschauwer, Brecht, Dorny, Pierre, Gabriël, Sarah, Laranjo-González, Minerva   +4 more
core   +4 more sources

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Documenting challenges in achieving rabies elimination by 2030 in low-middle income countries; a Kenyan case study from Lamu County, 2020–2022: mixed methods approach

One Health Outlook
Background Kenya launched a Rabies Elimination Strategy in 2014, aiming to end human rabies deaths by 2030. In March 2022, Lamu County reported increased cases of human dog bites and suspected rabies deaths to the Ministry of Health (MoH).
Nassoro Mwanyalu, Athman Mwatondo, Veronicah Chuchu, Kimani Maina, Mathew Muturi, Mathew Mutiiria, Daniel Chepkwony, Maurice Owiny, Peninah Munyua   +8 more
doaj   +1 more source

Variable geographic distribution of Blastocystis subtypes and its potential implications. [PDF]

, 2013
Blastocystis is a common intestinal micro-eukaryote found in both humans and non-human hosts and known to be genetically very diverse. It has been divided into numerous subtypes (STs), nine of which have been identified in humans to date.
Alfellani, Mohammed A, Clark, C Graham, Fagbenro-Beyioku, Adetayo F, Onuoha, Emeh Sunday Uche, Stensvold, C Rune, Vidal-Lapiedra, Amparo   +5 more
core   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Genotyping of Brucella strains isolated from humans and cattle of different geographical regions of Pakistan using MLVA‐15

Veterinary Medicine and Science, 2021
Background Prevalence of brucellosis and MLVA genotyping in animals and humans, isolated from different regions of Pakistan was performed. Animals having history of brucellosis from the field and local farms of Bannu, Mardan, Peshawar, Swat, Lahore and ...
Raheela Akhtar, Muhammad Muddassir Ali, Asad Ullah, Abdul Muttalib, Kashan Mehboob, Arif Ullah, Nasim Ahmad, Tahir Zahoor Chohan   +7 more
doaj   +1 more source

Campylobacter in aquatic and terrestrial mammals is driven by life traits: A systematic review and meta-analysis

Frontiers in Ecology and Evolution, 2023
IntroductionCampylobacter spp. infections are responsible for significant diarrheal disease burden across the globe, with prevalence thought to be increasing.
Michael R. Brooks, Sarah Medley, Monica Ponder, Kathleen A. Alexander, Kathleen A. Alexander   +4 more
doaj   +1 more source

Individual-level factors associated with the risk of acquiring human Plasmodium knowlesi malaria in Malaysia: a case-control study [PDF]

, 2017
Background: The emergence of human malaria due to the monkey parasite Plasmodium knowlesi threatens elimination efforts in southeast Asia. Changes in land use are thought to be driving the rise in reported P knowlesi cases, but the role of individual ...
Anstey, Nicholas M., Barber, Bridget E., Brock, Patrick M., Cox, Jonathan, Drakeley, Christopher J., Fornace, Kimberly M., Grigg, Matthew J., Jelip, Jenarun, von Seidlein, Lorenz, William, Timothy, Yeo, Tsin W.   +10 more
core   +3 more sources