Results 61 to 70 of about 267,402 (311)

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Forecasting Zoonotic Infectious Disease Response to Climate Change: Mosquito Vectors and a Changing Environment

Veterinary Sciences, 2019
Infectious diseases are changing due to the environment and altered interactions among hosts, reservoirs, vectors, and pathogens. This is particularly true for zoonotic diseases that infect humans, agricultural animals, and wildlife. Within the subset of
Andrew W. Bartlow, Carrie Manore, Chonggang Xu, Kimberly A. Kaufeld, Sara Del Valle, Amanda Ziemann, Geoffrey Fairchild, Jeanne M. Fair   +7 more
doaj   +1 more source

Increasing incidence of zoonotic visceral leishmaniasis on Crete, Greece [PDF]

, 2009
To determine whether the incidence of canine leishmaniasis has increased on Crete, Greece, we fitted infection models to serodiagnostic records of 8,848 dog samples for 1990–2006.
Adler, Andrew J. Sutton, Connor Carson, Courtenay, Courtenay, Hadjinicolaou, Hertig, Ioanna Ascoksilaki, Ippokratis Messaritakis, Ivovic, Leger, Leger, Leger, Maria Antoniou, Nikos Kanavakis, Orin Courtenay, Quinnell, Sutton, Vasiliki Christodoulou, Williams   +19 more
core   +4 more sources

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Yellow Fever in Non-Human Primates: A Veterinary Guide from a One Health Perspective

Veterinary Sciences
Yellow fever (YF) causes severe morbidity and mortality in Africa and South America. It is an arthropod-borne viral disease endemic to tropical regions of Africa and South America.
Remco A. Nederlof, Tommaso Virgilio, Hendrickus J. J. Stemkens, Luiz C. C. Pereira da Silva, Daniela R. Montagna, Abdussamad M. Abdussamad, John Chipangura, Jaco Bakker   +7 more
doaj   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Molecular prevalence and genotype identification of Enterocytozoon bieneusi in cattle and goats from Zhejiang Province, China

Frontiers in Veterinary Science
IntroductionEnterocytozoon bieneusi (E. bieneusi) is a widespread intracellular fungi that poses a significant zoonotic threat due to its infectivity toward both humans and animals.MethodsTo evaluate the zoonotic transmission potential of this fungi, a ...
Xianming Xin, Lijie Sun, Wei Liu, Jiayin Zhang, Shiyang Ma, Xinyi Fu, Wei Zhao, Baolong Yan   +7 more
doaj   +1 more source

Characterization of Ascaris from Ecuador and Zanzibar [PDF]

, 2014
To shed light on the epidemiology of ascariasis in Ecuador and Zanzibar, 177 adult worms retrieved by chemo-expulsion from either people or pigs were collected, measured and subjected to polymerase chain reaction-restriction fragment length polymorphism (
A.M. Sparks, Arizono, Betson, C. Sandoval, Draper, G. Oviedo, J.R. Stothard, M. Betson, P.J. Cooper, Takata   +9 more
core   +5 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Discovery of a Novel Parahenipavirus, Parahenipavirus_GH, in Shrews in South Korea, 2022

Viruses
Highly pathogenic henipaviruses (Nipah and Hendra viruses) and parahenipaviruses (Langya virus) have demonstrated significant zoonotic potential.
Gyuri Sim, Chi-Hwan Choi, Minji Lee, Hak Seon Lee, Seong Yoon Kim, Seung Hun Lee, Hee Il Lee, Yoon-Seok Chung   +7 more
doaj   +1 more source