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Vaccination Against Ticks and the Control of Ticks and Tick-borne Disease

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Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries

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Abstract

Economic losses due to ticks and tick-borne disease of livestock fall disproportionately on developing countries. Currently, tick control relies mostly on pesticides and parasite-resistant cattle. Release of a commercial recombinant vaccine against Boophilus microplus in Australia in 1994 showed that anti-tick vaccines are a feasible alternative. For vaccines, it is important to understand the efficacy needed for a beneficial outcome. In this, it is relevant that some tick antigens affect multiple tick species; that existing vaccines could be improved by the inclusion of additional tick antigens; and that vaccination against ticks can have an impact on tick-borne disease. Practically, although recombinant vaccine manufacture involves relatively few steps, issues of intellectual property rights (IPR) and requirements for registration of a product may affect economic viability of manufacture. Hence practical vaccines for the developing world will require both successful science and a creative “business solution” for delivery in a cost-effective way.

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References

  • Batson, A. 2002. The costs and economics of modern vaccine development in Orphan Vaccines — Bridging the Gap. Developmental Biology, 110: 15–24.

    CAS  Google Scholar 

  • Callow, L.L., Dalgleish, R.J. & de Vos, A.J. 1997. Development of effective living vaccines against bovine babesiosis — the longest field trial? International Journal of Parasitology, 27: 747–767

    Article  PubMed  CAS  Google Scholar 

  • Cobon, G.S., Moore, J.T., Johnston, L.A.Y., Willadsen, P., Kemp, D.H., Sriskantha, A., Riding, G.A. & Rand. K.N. 1996. DNA encoding a cell membrane glycoprotein of a tick gut. US Patent and Trademark Office Application No. 325 071 435/240.2.

    Google Scholar 

  • de Castro, J.J. 1997. Sustainable tick and tickborne disease control in livestock improvement in developing countries. Veterinary Parasitology, 71: 77–97.

    PubMed  Google Scholar 

  • de la Fuente, J., Rodriguez, M., Montero, C., Redondo, M., García-García, J.C., Mendez, L., Serrano, E., Valdes, M., Enriquez, A., Canales, M., Ramos, E., Boue, O., Machado, H. & Lleonart, R. 1999. Vaccination against ticks (Boophilus spp.): the experience with the Bm86-based vaccine Gavac I. Genetic Analysis Biomolecular Engineering, 15: 143–148.

    PubMed  Google Scholar 

  • de la Fuente, J., Rodriguez, M., Redondo, M., Montero, C., García-García, J.C., Mendez, L., Serrano, E., Valdes, M., Enriquez, A., Canales, M., Ramos, E., Boue, O., Machado, H., Lleonart, R., de Armas, C.A., Rey, S., Rodriguez, J.L., Artiles, M. & García, L. 1998. Field studies and cost-effectiveness of vaccination with Gavac against the cattle tick Boophilus microplus. Vaccine, 16: 366–373.

    PubMed  Google Scholar 

  • de Vos, S., Zeinstra, L., Taoufik, O., Willadsen, P. & Jongejan, F. 2001. Evidence for the utility of the Bm86 antigen from B. microplus in vaccination against other tick species. Experimental Applied Acarology, 25: 245–261.

    PubMed  Google Scholar 

  • Fragoso, H., Hoshman-Rad, P., Ortiz, M., Rodgrigues, M., Redondo, M., Herrera, L. & de la Fuente, J. 1998. Protection against Boophilus annulatus infestations in cattle vaccinated with the B. microplus Bm86-containing vaccine Gavac.Vaccine, 16: 1990–1992.

    Article  PubMed  CAS  ISI  Google Scholar 

  • García-García, J.C., Gonzalez, I.L., Gonzalez, D.M., Valdes, M., Mendez, L., Lamberti, J., D’Agostino, B., Citroni, D., Fragoso, H., Ortiz, M., Rodriguez, M. & de la Fuente, J. 1999. Sequence variations in the B. microplus Bm86 locus and implications for immunoprotection in cattle vaccinated with this antigen. Experimental Applied Acarology, 11: 883–895.

    Google Scholar 

  • García-García, J.C., Montero, C., Redondo, M., Vargas, M., Canales, M., Boue, O., Rodriguez, M., Joglar, M., Machado, H., Gonzalez, I.L., Valdes, M., Mendez, L. & de la Fuente, J. 2000. Control of ticks resistant to immunization with Bm86 in cattle vaccinated with the recombinant antigen Bm95 isolated from the cattle tick, B. microplus. Vaccine, 18: 2275–2287.

    PubMed  Google Scholar 

  • Gu, G., Junkal, S., Mbying, Y., Jukui, Z., Shuun, M., Ali, N., Lixin, T. & Maliyam. 1997. Research on the schizont cell culture vaccine against Theileria annulata infection in Xinjiang, China. Tropical Animal Health and Production, 29: 98S–100S.

    Google Scholar 

  • Hungerford, J., Pulga, M., Zwtsch, E. & Cobon, G. 1995. Efficacy of TickGARDTM in Brazil.In: Resistencia Y Control en Garrapatas Y Moscas de Importancia Veterinaria. Seminario Internacional de Parasitologia Animal, Sagar Canifarma, Mexico, 11–13 October 1995. Sagar/Canifarma/FAO/IICA/INIFAP, Acapulco.

    Google Scholar 

  • Jonsson, N.N., Matschoss, A.L., Pepper, P., Green, P.E., Albrecht, M.S., Hunterford, J. & Ansell, J. 2000. Evaluation of TickGARD(PLUS), a novel vaccine against B. microplus, in lactating Holstein-Friesian cows. Veterinary Parasitology, 88: 275–285.

    PubMed  CAS  ISI  Google Scholar 

  • Khalaf, A.S.S. 1999. Control of B. microplus ticks in cattle calves by immunization with a recombinant Bm86 glucoprotein antigen preparation. Deutsche Tierarztliche Wochenschrift, 106: 248–251.

    ISI  Google Scholar 

  • Kocan, K.M. 1995. Targeting ticks for control of selected hemoparasitic diseases of cattle. Veterinary Parasitology, 57: 121–151.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Labuda, M., Trimnell, A.R., Lickova, M., Kazimirova, M., Slovak, M. & Nuttall, P.A. 2002. Recombinant tick salivary antigens (64TRP) as a TRANSBLOK vaccine against tick-borne encephalitis virus. p. 51, in: Abstracts of the 4th International Conference on Ticks and Tick-Borne Pathogens. Banff, Canada, 21–26 July 2002.

    Google Scholar 

  • Patarroyo, J.H., Portela, R.W., de Castro, R.O., Pimentel, J.C., Guzman, F., Patarroyo, M.E., Vargas, M.I., Prates, A.A. & Mendes, M.A.D. 2002. Immunization of cattle with synthetic peptides derived from the B. microplus gut protein (Bm86). Veterinary Immunology and Immunopathology, 88: 163–172.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Perry, B.D., Randolph, T.F., McDermott, J.J., Sones, K.R. & Thornton, P.K. 2002. Investing in animal health to alleviate poverty. ILRI [International Livestock Research Institute] Nairobi, Kenya.

    Google Scholar 

  • Pipano, E., Alekceev, E., Galker, F., Fish, L., Samish, M. & Shkap, V. 2003. Immunity against Boophilus annulatus induced by the Bm86 (Tick-GARD) vaccine. Experimental Applied Acarology, 29: 141–149.

    PubMed  CAS  Google Scholar 

  • Rand, K.N., Moore, T., Sriskantha, A., Spring, K., Tellam, R., Willadsen, P. & Cobon, G.S. 1989. Cloning and expression of a protective antigen from the cattle tick B. microplus. Proceedings of the National Academy of Sciences, USA, 86: 9657–9661.

    CAS  Google Scholar 

  • Rodriguez, M., Massard, C.L., Henrique da Fonseca, A., Ramos, N.F., Machado, H., Labarta, V. & de la Fuente, J. 1995a. Effect of a vaccination with a recombinant Bm86 antigen preparation on natural infestations of B. microplus in grazing dairy and beef pure and cross-bred cattle in Brazil. Vaccine, 13: 1804–1808.

    PubMed  CAS  ISI  Google Scholar 

  • Rodriguez, M., Penichet, M.L., Mouris, A.E., Labarta, V., Luaces, L.L., Rubiera, R., Cordoves, C., Sanchez, P.A., Ramos, E., Soto, A., Canales, M., Palenzuela, D., Triiguero, A., Lleonart, R., Herrera, L. & de la Fuente, J. 1995b. Control of B. microplus populations in grazing cattle vaccinated with a recombinant Bm86 antigen preparation. Veterinary Parasitology, 57: 339–349.

    PubMed  CAS  ISI  Google Scholar 

  • Shirong, S. 1997. Application and effect of the schizont vaccine against Theileria annulata in China. Tropical Animal Health and Production, 29: 101S–103S.

    Google Scholar 

  • Sutherst, R. W., Norton, G.A., Barlow, N.D., Conway, G.R., Birley, M., Comins, H.N. 1979. An analysis of management strategies for cattle tick (Boophilus microplus) control in Australia. Journal of Applied Ecology, 16: 359–382.

    ISI  Google Scholar 

  • Trimnell, A.R., Hails, R.S. & Nuttall, P.A. 2002. Dual action ectoparasite vaccine targeting ‘exposed’ and ‘concealed’ antigens. Vaccine, 20: 3360–3568.

    Article  Google Scholar 

  • Willadsen, P. 2001. The molecular revolution in the development of vaccines against ectoparasites. Veterinary Parasitology, 101: 353–367.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Willadsen, P. In press. Anti-tick Vaccines. Parasitology (in press).

    Google Scholar 

  • Willadsen, P., Bird, P., Cobon, G.S. & Hungerford, J. 1995. Commercialisation of a recombinant vaccine against B. microplus. Parasitology, 110: 43–50.

    Article  Google Scholar 

  • Willadsen, P., Riding, G.A., McKenna, R.V., Kemp, D.H., Tellam, R.L., Nielsen, J.N., Lahnstein, J., Cobon, G.S. & Gough, J.M. 1989. Immunologic control of a parasitic arthropod. Identification of a protective antigen from B. microplus. Journal of Immunology, 143: 1346–1351.

    CAS  ISI  Google Scholar 

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Authors and Affiliations

  1. Queensland Bioscience Precinct, CSIRO Livestock Industries, 306 Carmody Rd., St. Lucia, Queensland, 4067, Australia

    Peter Willadsen

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  1. Peter Willadsen
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Editors and Affiliations

  1. Animal Production and Health Section, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria

    Harinder P.S. Makkar  & Gerrit J. Viljoen  & 

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© 2005 IAEA

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Willadsen, P. (2005). Vaccination Against Ticks and the Control of Ticks and Tick-borne Disease. In: Makkar, H.P., Viljoen, G.J. (eds) Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3312-5_22

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