Human tooth is made of three different hard tissues: enamel—recovering the crown and corresponding to the most mineralized tissue found in the body; cementum— deposited on the root surface; and dentine—underlying the enamel and cementum and forming the bulk of the tooth. Dentine covers the pulp, which lies in the center of the tooth. Pulp, the vital mesenchymal tissue, contains: (1) a specialized layer of cells at its periphery (the odontoblast layer) that is responsible for the dentine matrix synthesis and (2) blood vessels and nerves. During development, tooth pulp acquires a profuse nociceptive and sympathetic innervation from the trigeminal ganglion (TG) and the superior cervical ganglion, respectively.
The purpose of this chapter is to briefly review the core components and signaling mechanism of the Reelin pathway, and then to present evidence on possible downstream components. Issues related to the first two questions, the timing and site of Reelin action and the possible changes in cell biology, are left for other chapters.
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Bleicher, F., Magloire, H., Couble, ML., Maurin, JC. (2008). Reelin and Odontogenesis. In: Fatemi, S.H. (eds) Reelin Glycoprotein. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76761-1_19
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