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Restriction Fragment Length Polymorphism in Plants and Its Implications

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Plant Genetic Engineering

Part of the book series: Subcellular Biochemistry ((SCBI,volume 17))

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Abstract

Botstein et al. (1980) were the first to outline convincingly how cloned pieces of eukaryotic DNA could be used as genetic markers. They pointed out that organisms differing in base sequence would be expected to yield fragments of different sizes when their DNA was digested with a suitable restriction enzyme. These DNA fragments could then be fractionated by size on an agarose gel and detected by hybridization with a cloned probe homologous to a portion of the fragment. Such differences in the size of restriction fragments were termed restriction fragment length polymorphisms (RFLPs), and they would be expected to arise from nucleotide changes in the DNA or by insertions, deletions, or other forms of rearrangement.

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  1. Department of Botany, University of Georgia, 30602, Athens, Georgia, USA

    Gary Kochert

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  1. Gary Kochert
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  1. Bose Institute, Centenary Building, Calcutta, 700 054, India

    B. B. Biswas

  2. Institute for Cell and Tumor Biology, German Cancer Research Center, Heidelberg, Germany

    J. R. Harris

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Kochert, G. (1991). Restriction Fragment Length Polymorphism in Plants and Its Implications. In: Biswas, B.B., Harris, J.R. (eds) Plant Genetic Engineering. Subcellular Biochemistry, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-9365-8_8

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  • DOI: https://doi.org/10.1007/978-1-4613-9365-8_8

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