Abstract
In this chapter, we review transcription of mammalian rRNA genes by RNA polymerase I (Pol I), a process that integrates information from cellular signaling cascades to regulate ribosome production. Although the emerging picture of Pol I transcriptional regulation reveals an unexpected level of complexity, we are beginning to understand the multiple links between the Pol I transcription machinery and the sophisticated network of signaling cascades that guide cell growth and proliferation. A comprehensive analysis of the connection between Pol I transcription, cell proliferation, and growth-factor signaling has not only expanded our understanding of the molecular mechanisms that control rRNA synthesis and ribosome biogenesis but will also facilitate the development of new strategies that inhibit ribosome biogenesis, and hence proliferation of cancer cells, through targeted downregulation of components of the Pol I transcription apparatus.
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Acknowledgments
Our work has been supported by grants from the Deutsche ForschungsgeÂmeinschaft, the EU Network ‚The Epigenome’, the BMBF (‘EpiSys’), an ERC Advanced Grant, and the Fonds der Chemischen Industrie.
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Voit, R., Grummt, I. (2011). The RNA Polymerase I Transcription Machinery. In: Olson, M. (eds) The Nucleolus. Protein Reviews, vol 15. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0514-6_6
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