Definition
Cerebral ischemia, which occurs during stroke, is insufficient blood flow to the brain and leads to loss of oxygen and glucose supply. This severely compromises cellular respiration, causing neuronal damage. Cells move towards cell death, which can be simplified as being apoptotic (controlled and “programmed”) or necrotic (uncontrolled). Necroptopic cell death, which is a stereotypical necrotic death pathway, has also recently been characterized during stroke (Christofferson and Yuan 2010). In addition to being both a single-cell and multicell phenomenon, ischemic insult also involves transcriptional changes to regulatory networks of genes. Taken together, modeling the molecular and genetic aspects of ischemia is fundamental to understanding how to modulate neuroprotective elements in the case of stroke, which is the primary therapeutic approach in saving at-risk tissue. Computer-based cellular modeling can...
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Neymotin, S.A., Taxin, Z., Mohan, A., Lipton, P. (2013). Brain Ischemia and Stroke. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_736-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_736-1
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Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-7320-6
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Latest
Brain Ischemia and Stroke- Published:
- 30 July 2019
DOI: https://doi.org/10.1007/978-1-4614-7320-6_736-2
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Brain Ischemia and Stroke- Published:
- 08 February 2014
DOI: https://doi.org/10.1007/978-1-4614-7320-6_736-1