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The Chemistry of Heparin

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Heparin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 52))

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Abstract

Although heparin was isolated in a pure, active form nearly six decades ago by McLean (41), the problems faced in solving its chemical structure have been complex enough that a recent circular (52) addressed to physicians states that “heparin is a heterogeneous substance whose exact structure is still unknown.” Nevertheless, since I wrote (25), in 1958 that “the major complex chemical structure of heparin is still one of the least understood”, much progress has been made, especially through the efforts of Cifonelli, Danishefsky, Dietrich, Lindahl, Linker, Perlin, Wolfrom, and their respective associates.- Even if we do not have, as yet, a complete picture of the heparin molecule, and the relationship between structure and biological properties is still unclear, we have made enough progress to hope for a solution in the near future.

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Author information

Authors and Affiliations

  1. Laboratory for Carbohydrate Research, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Roger W. Jeanloz

Authors
  1. Roger W. Jeanloz
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Editor information

Editors and Affiliations

  1. Department of Biological Chemistry, Washington University School of Medicine, St. Louis, Missouri, USA

    Ralph A. Bradshaw

  2. Department of Medicine, The Jewish Hospital, St. Louis, Missouri, USA

    Stanford Wessler

  3. Washington University School of Medicine, St. Louis, Missouri, USA

    Stanford Wessler

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© 1975 Plenum Press, New York

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Jeanloz, R.W. (1975). The Chemistry of Heparin. In: Bradshaw, R.A., Wessler, S. (eds) Heparin. Advances in Experimental Medicine and Biology, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0946-8_1

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  • DOI: https://doi.org/10.1007/978-1-4684-0946-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0948-2

  • Online ISBN: 978-1-4684-0946-8

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